1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl

SNIPER(ABL)-062 

目录号: HY-124847
产品使用指南

SNIPER(ABL)-062,由 ABL 抑制剂通过 linker 与 cIAP1 配体组合而成,可有效降解 BCR-ABL 蛋白。

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SNIPER(ABL)-062 Chemical Structure

SNIPER(ABL)-062 Chemical Structure

CAS No. : 2140260-89-3

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Description

SNIPER(ABL)-062, in which an ABL inhibitor is linked to a ligand of cIAP1 via a linker containing a variable polyethylene glycol (PEG) unit, shows a potent activity to degrade the BCR-ABL protein[1].

References
Molecular Weight

1089.64

Formula

C₅₃H₆₃ClF₂N₁₀O₉S

CAS No.

2140260-89-3

SMILES

O=C(C1CCN(C2=NC=C(C(NC3=CC=C(OC(F)(Cl)F)C=C3)=O)C=C2C4=CC=NN4)C1)NCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
SNIPER(ABL)-062
目录号:
HY-124847
需求量:

SNIPER(ABL)-062

Cat. No.: HY-124847