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    Androgen Receptor

SNIPER(AR)-51 (Synonyms: AR-51)

目录号: HY-119391
产品使用指南

SNIPER(AR)-51 (AR-51) 由 cIAP1 配体和雄激素配体,通过 linker 连接组成。SNIPER(AR)-51 诱导雄激素受体 (androgen receptor) 蛋白降解。

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SNIPER(AR)-51 Chemical Structure

SNIPER(AR)-51 Chemical Structure

CAS No. : 2113688-43-8

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Description

SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker[1]. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation[1].

In Vitro

SNIPER(AR)-51 (3 μM; 24 hours) exhibits a pronounced effect on the cell morphology of VCaP cells to induce apoptosis[1].
SNIPER(AR)-51 (3 μM; 24 hours) induces caspase-3 activation and PARP cleavage in prostate cancer VCaP cells[1].

Apoptosis Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 3 μM
Incubation Time: 24 hours
Result: Induced apoptosis.

Western Blot Analysis[1]

Cell Line: VCaP cells
Concentration: 1 μM and 3 μM
Incubation Time: 24 hours
Result: Induced caspase-3 activation and PARP cleavage at 3 μM.
References
Molecular Weight

984.21

Formula

C₅₅H₆₅N₇O₈S

CAS No.

2113688-43-8

SMILES

C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCCOC5=CC=C(CN6C(C)=C(C#N)C(C7=CC=C(C#N)C=C7)=C6C)C=C5)=C4)=O)=CS3)CCC2)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
SNIPER(AR)-51
目录号:
HY-119391
需求量:

SNIPER(AR)-51

Cat. No.: HY-119391