1. PROTAC
    Epigenetics
  2. SNIPER
    Epigenetic Reader Domain
  3. SNIPER(BRD)-1

SNIPER(BRD)-1 

目录号: HY-111875
产品使用指南

SNIPER(BRD)-1 由 IAP 拮抗剂 LCL-161 衍生物和 BET 抑制剂 (+)-JQ-1,通过 linker 连接组成。SNIPER(BRD)-1 通过泛素-蛋白酶体系统诱导 BRD4 降解。SNIPER(BRD)-1 也降解 cIAP1,cIAP2 和 XIAP,IC50 分别为 6.8 nM,17 nM 和 49 nM。

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SNIPER(BRD)-1 Chemical Structure

SNIPER(BRD)-1 Chemical Structure

CAS No. : 2095244-54-3

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Description

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

IC50 & Target[1]

BRD4

 

cIAP1

6.8 nM (IC50)

cIAP2

17 nM (IC50)

XIAP

49 nM (Ki)

SNIPER

 

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1056.73

Formula

C₅₃H₆₆ClN₉O₈S₂

CAS No.

2095244-54-3

SMILES

O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5

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Room temperature in continental US; may vary elsewhere

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产品名称:
SNIPER(BRD)-1
目录号:
HY-111875
需求量:

SNIPER(BRD)-1

Cat. No.: HY-111875