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Sulfosuccinimidyl oleate sodium 

目录号: HY-112847A 纯度: >98.0%
产品使用指南

Sulfosuccinimidyl oleate sodium 是一种长链脂肪酸,抑制脂肪酸向细胞转运。Sulfosuccinimidyl oleate 结合小胶质细胞表面上的 CD36受体。具有抗炎作用。

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Sulfosuccinimidyl oleate sodium Chemical Structure

Sulfosuccinimidyl oleate sodium Chemical Structure

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2090 In-stock
5 mg ¥1900 In-stock
10 mg ¥3200 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Sulfosuccinimidyl oleate sodium is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1].

In Vitro

Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability[1].
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

Cell Viability Assay[1]

Cell Line: BV2 cells
Concentration: 20 μM and 50 μM
Incubation Time: 24 hours
Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it.

Western Blot Analysis[1]

Cell Line: BV2 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.
In Vivo

Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke[1].

Animal Model: 4-month-old male BALB/cABom mice with pMCAo model[1]
Dosage: 50 mg/kg
Administration: Administered once by single oral gavage
Result: Reduced brain damage following ischemia. Attenuated infarct size.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (129.78 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0765 mL 10.3825 mL 20.7650 mL
5 mM 0.4153 mL 2.0765 mL 4.1530 mL
10 mM 0.2076 mL 1.0382 mL 2.0765 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

481.58

Formula

C₂₂H₃₆NNaO₇S

SMILES

O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Sulfosuccinimidyl oleate sodium
目录号:
HY-112847A
需求量:

Sulfosuccinimidyl oleate sodium

Cat. No.: HY-112847A