1. Cell Cycle/DNA Damage
  2. Topoisomerase

Top1 inhibitor 1 

目录号: HY-126142
产品使用指南

Top1 inhibitor 1 (化合物 28) 是一种有效的人拓扑异构酶 1 (Top1) 抑制剂,IC50 值为 29 nM。

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Top1 inhibitor 1 Chemical Structure

Top1 inhibitor 1 Chemical Structure

CAS No. : 2302772-05-8

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Description

Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

IC50 & Target

IC50: 29 nM (human topoisomerase I)[1]

In Vitro

Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1].

References
Molecular Weight

426.47

Formula

C₂₄H₂₂N₆O₂

CAS No.

2302772-05-8

SMILES

COC(C=C1)=CC=C1C2=CC=C(N=CC(C3=NN=CO3)=C4NCCCN5C=NC=C5)C4=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Top1 inhibitor 1
目录号:
HY-126142
需求量:

Top1 inhibitor 1

Cat. No.: HY-126142