2. Neuronal Signaling
  3. Dopamine Transporter
  4. Vanoxerine

Vanoxerine  (Synonyms: GBR 12909; I893)

目录号: HY-13217A
产品使用指南

摩尔计算器

Vanoxerine (GBR-12909) 是竞争性的，有效选择性的多巴胺再摄取 (dopamine reuptake) 抑制剂。Vanoxerine (GBR-12909) 与多巴胺转运体 (DAT) 上的靶点结合。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Vanoxerine dihydrochloride 通常具有更好的水溶性和稳定性。

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Vanoxerine Chemical Structure

Vanoxerine Chemical Structure

CAS No. : 67469-69-6

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规格 是否有货
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250 mg   询价  

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Vanoxerine 的其他形式现货产品:

Other Forms of Vanoxerine:

Vanoxerine 相关抗体

Top Publications Citing Use of Products

    Vanoxerine purchased from MCE. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309.  [Abstract]

    p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT)[1].

    IC50 & Target

    Ki: 1 nM (dopamine reuptake)[1]
    体外研究
    (In Vitro)

    Vanoxerine (GBR-12909) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT[2].
    Vanoxerine (GBR-12909) is also an oral, mixed ion channel blocker with IKr, INa, and L-type calcium channel activity[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Vanoxerine 相关抗体:
    体内研究
    (In Vivo)

    Vanoxerine (GBR-12909) (2.5-20 mg/kg; i.p.) significantly increases the ambulatory activity[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male mice(ddY strain at 6 weeks of age)[3]
    Dosage: 2.5, 5, 10, 20 mg/kg
    Administration: Intraperitoneal injection
    Result: The ambulatory activity of mice increased in a dose-dependent manner, with a maximal increase at 30 min after the administration.
    Clinical Trial
    分子量

    450.56

    Formula

    C28H32F2N2O
    CAS 号
    中文名称

    伐诺司林；伐洛司林
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Vanoxerine 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vanoxerine67469-69-6GBR 12909 I893伐诺司林伐洛司林GBR12909GBR-12909I893I 893I-893Dopamine TransporterDATSLC6A3Inhibitorinhibitorinhibit

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    目录号：
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