2. 抗体抑制剂
  3. 动物体内抗体
  4. Vopratelimab (Mouse IgG2a)

Vopratelimab (Mouse IgG2a) 

目录号: HY-P99382A
技术支持

Vopratelimab (Mouse IgG2a) 是一种选择性靶向可诱导 T 细胞共刺激因子 (ICOS) 的单克隆抗体。Vopratelimab (Mouse IgG2a) 的可变区与 Vopratelimab (HY-P99382) 的可变区一致，而恒定区为小鼠 IgG2a 序列。Vopratelimab (Mouse IgG2a) 具有抗肿瘤免疫反应并可增强与 anti-PD-1 (HY-P9902A) 的联合疗效。

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Vopratelimab (Mouse IgG2a) Chemical Structure

Vopratelimab (Mouse IgG2a) Chemical Structure

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Customer Review

Other Forms of Vopratelimab (Mouse IgG2a):

Vopratelimab (Mouse IgG2a) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vopratelimab (Mouse IgG2a) is a monoclonal antibody that selectively targets Inducible CO-Stimulator of T cells (ICOS). The variable region of Vopratelimab (Mouse IgG2a) is consistent with that of Vopratelimab (HY-P99382), while the constant region is of Mouse IgG2a sequence. Vopratelimab (Mouse IgG2a) has antitumor immune response and enhances combinatorial efficacy with anti-PD-1 (HY-P9902A) therapy[1].

体内研究
(In Vivo)

Aducanumab (Mouse IGG2a) (0.25-0.3 mg/kg，腹腔注射，分 4 次给药，分别在 7、10、14 和 17 天) 在 Sa1/N 纤维肉瘤小鼠模型中表现出显著的抗肿瘤活性 (70% 的肿瘤消退)，并具有全身长期免疫力[1]。
Aducanumab (Mouse IGG2a) (0.25 mg/kg，腹腔注射，分 2 次给药，分别在 6 天和 11 天) 在 B16-SIY 肿瘤小鼠模型中表现出显著的抗肿瘤活性并具有长期保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female A/J mice (6-8 weeks old) were injected subcutaneously with Sa1/N cells (1 × 106 cells/mouse) to induce Sa1/N fibrosarcoma mice model[1].
Dosage: 0.25-0.3 mg/kg
Administration: i.p., 4 doses (7, 10, 14 and 17 days) for 11 days after tumors reaching approximately 100 mm3.
Result: Had significant anti-tumor activity with 7 out of 10 mice showing complete tumor regression.
Induced systemic long-term immunity with re-challenge with Sa1/N tumors ~45 days after the last treatment in Tumor-free mice.
Decreased the percentage of intratumoral CD4+FoxP3+ Treg within CD3+ cells, but increased in the CD8: Treg and CD4 Teff: Treg ratios in the tumors.
Animal Model: Mice were injected subcutaneously with B16-SIY cells to induce B16-SIY tumor mice model[1].
Dosage: 0.25 mg/kg
Administration: i.p., 6 and 11 days
Result: Induced no tumor growth and survived re-challenge with B16-SIY tumors 10 weeks.
Induced T cells proliferation in both peripheral blood and spleen and tetramer+ T cells proliferation in spleen as well as the frequency of activated memory CD8 T cells.
Induced Treg depletion and increased effector T cell to Treg ratios.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vopratelimab (Mouse IgG2a) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vopratelimab (Mouse IgG2a)OthersMonoclonal AntibodyVopratelimabICOSAntitumorSa1/N fibrosarcoma mice modelB16-SIY tumor mice modelInhibitorinhibitorinhibit

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