1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Zaldaride maleate

Zaldaride maleate (Synonyms: CGS-9343B; KW 5617)

目录号: HY-105118A 纯度: >98.0%
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Zaldaride maleate (CGS-9343B) 是一个有效的、选择性的钙调蛋白 (calmodulin) 的抑制剂,可抑制钙调蛋白刺激cAMP磷酸二酯酶的活性,IC50 值为 3.3 nM。Zaldaride maleate (CGS-9343B) 可抑制雌激素诱导的ER转录激活,可逆地阻断PC12细胞中电压激活的的Na+、Ca2+和K+电流,抑制nAChR。

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Zaldaride maleate Chemical Structure

Zaldaride maleate Chemical Structure

CAS No. : 109826-27-9

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Description

Zaldaride maleate (CGS-9343B) is a potent and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3].

IC50 & Target

IC50: 3.3 nM (calmodulin)[1][2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

544.60

Formula

C₃₀H₃₂N₄O₆

CAS No.

109826-27-9

SMILES

O=C(O)/C=C\C(O)=O.CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(N5C6=C(C=CC=C6)NC5=O)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Zaldaride maleate
目录号:
HY-105118A
需求量:

Zaldaride maleate

Cat. No.: HY-105118A