2. Apoptosis
  3. Apoptosis
  4. 1,6,7-Trihydroxyxanthone

1,6,7-Trihydroxyxanthone  (Synonyms: 1,6,7-三羟基呫吨酮)

目录号: HY-N0992
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摩尔计算器

1,6,7-Trihydroxyxanthone 是一种有效的抗癌剂。1,6,7-Trihydroxyxanthone 抑制细胞增殖并诱导细胞细胞凋亡 (Apoptosis)。1,6,7-Trihydroxyxanthone 降低 Bmi-1 的表达，增加 P14，P16 的蛋白表达水平。

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1,6,7-Trihydroxyxanthone Chemical Structure

1,6,7-Trihydroxyxanthone Chemical Structure

CAS No. : 25577-04-2

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1,6,7-Trihydroxyxanthone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].

体外研究
(In Vitro)

1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) 抑制 HepG2、Bel7404 细胞的细胞增殖[1]。
1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) 诱导 HepG2 细胞凋亡[1].
1,6,7-Trihydroxyxanthone 降低 Bmi-1 表达并增加 P14、P16 的蛋白表达水平[1]。
1,6,7-Trihydroxyxanthone 在 HepG2、Bel7404 细胞中诱导 MiR-218 上调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1,6,7-Trihydroxyxanthone 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HepG2, Bel7404 cells
Concentration: 0, 1.25, 2.5, 5, 10 µg/mL
Incubation Time: 0, 24, 48, 72 h
Result: Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 5 μg/ml
Incubation Time: 72 h
Result: Induced cell apoptosis.

Western Blot Analysis[1]

Cell Line: HepG2, Bel7404 cells
Concentration:
Incubation Time:
Result: Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels.
分子量

244.20

Formula

C13H8O5
CAS 号
Unlabeled CAS

中文名称

1,6,7-三羟基呫吨酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1,6,7-Trihydroxyxanthone 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,6,7-Trihydroxyxanthone25577-04-21,6,7-三羟基呫吨酮ApoptosisapoptosisantiproliferativeBmi-1P14P16MiR-218HepG2Bel7404 cellsInhibitorinhibitorinhibit

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