1. Metabolic Enzyme/Protease Anti-infection
  2. Amylases Bacterial
  3. 1-Hydroxyphenazine

1-Hydroxyphenazine  (Synonyms: Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin)

目录号: HY-W068682
产品使用指南

1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) 是一种 α-淀粉酶 (α-Amylase) 抑制剂,IC50 为 3.1 μg/mL。1-Hydroxyphenazine 对 A549、1321N1 和 RAW264.7 细胞具有抗癌和抗炎活性,对菌株 Candida albicansAspergillus fumigatusEscherichia coliXanthomonas campestris 具有抗真菌和抗菌活性。

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1-Hydroxyphenazine Chemical Structure

1-Hydroxyphenazine Chemical Structure

CAS No. : 528-71-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL[1]. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris[2][3][4][5].

体外研究
(In Vitro)

1-Hydroxyphenazine (0.1-100 μM) 过形成酸性囊泡细胞器 (细胞自噬的标志) 抑制脑星形细胞瘤 1321N1 细胞的增殖,对中枢神经系统 (CNS) 表现出潜在毒性[2]
Hydroxyphenazine (0-10 μg/mL) 可抑制 TNF-α 的分泌和 M1 细胞极化,抑制 LPS 诱导的 RAW264.7 细胞炎症,且无明显毒性[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: RAW264.7
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Inhibited proliferation of RAW264.7 in a dose-dependent maner.

RT-PCR[3]

Cell Line: RAW264.7
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Decreased levels of TNF-α, IL-1β and IL-6 mRNA expressions.
分子量

196.20

Formula

C12H8N2O

CAS 号
中文名称

1-羟基吩嗪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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