2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. 16-HETE

16-HETE 是花生四烯酸亚末端羟基化的 CYP-450 代谢物。16-HETE 具有血管舒张和多形核白细胞抑制作用，可作为非酒精性脂肪肝疾病早期阶段的生物标志物。

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16-HETE Chemical Structure

16-HETE Chemical Structure

CAS No. : 128914-46-5

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16-HETE 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease[1][2][3].

体外研究
(In Vitro)

16-HETE (0.01-1 μM) 特异性抑制多形核白细胞聚集和粘附，对血小板功能和血压没有显著影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

16-HETE 相关抗体:
体内研究
(In Vivo)

16-HETE (1-20 μg，动脉注射) 在新西兰白兔中立体特异性地 (S-对映异构体) 参与血管舒张、肾灌注调节以及肾小管转运机制[2]。
16-HETE (1 μg/kg/min) 可抑制新西兰白兔血栓栓塞性中风模型中的颅内压 (ICP) 升高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbit[2]
Dosage: 1-20 μg
Administration: injection into artery
Result: 16S inhibited 60% ATPase activity at the concentration of 2 μM, while 16R enantiomer remained inactive.
Animal Model: New Zealand White rabbit[1]
Dosage: 1 μg/kg/min
Administration: 6 hours constant infusion from Hours 1 to 2 after autologous clot embolization
Result: Reduced infarction area and less increased ICP.
分子量

320.47

Formula

C20H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

16-HETE 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

16-HETE128914-46-5Na+/K+ ATPaseSodium potassium pumpcentral hypertensionthrombosisnon-alcoholic fatty liver diseaseInhibitorinhibitorinhibit

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