2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB
  4. 3,4,5-Tricaffeoylquinic acid

3,4,5-Tricaffeoylquinic acid  (Synonyms: 3,4,5-triCQA)

目录号: HY-N6588 纯度: 98.57%
COA 产品使用指南

摩尔计算器

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) 通过抑制 Akt 和 NF-κB 途径抑制肿瘤坏死因子-α 刺激角质形成细胞中炎性介质的产生。3,4,5-Tricaffeoylquinic acid 诱导人神经干细胞 G0/G1 细胞周期阻滞、肌动蛋白骨架组织、染色质重塑、神经元分化和骨形态发生蛋白信号传导。3,4,5-Tricaffeoylquinic acid 在衰老相关疾病的研究中具有潜在的应用前景。

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3,4,5-Tricaffeoylquinic acid Chemical Structure

3,4,5-Tricaffeoylquinic acid Chemical Structure

CAS No. : 86632-03-3

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规格 价格 是否有货 数量
1 mg ￥2900
In-stock
5 mg ￥8500
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

3,4,5-Tricaffeoylquinic acid 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases[1][2].

体外研究
(In Vitro)

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3,4,5-Tricaffeoylquinic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Keratinocytes
Concentration: 15, 25 and 50 μM
Incubation Time: 24 hours
Result: Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM.

Western Blot Analysis[1]

Cell Line: Keratinocytes
Concentration: 15 μM
Incubation Time: 20 min before 10 ng/mL TNF-α addition for 15 min
Result: Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
分子量

678.59

Formula

C34H30O15
CAS 号
性状

固体

颜色

Yellow to brown

中文名称

3,4,5-三咖啡酰奎宁酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (73.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4736 mL 7.3682 mL 14.7364 mL
5 mM 0.2947 mL 1.4736 mL 2.9473 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.71%

COA (198 KB) HNMR (102 KB) RP-HPLC (192 KB)

产品使用指南 (1538 KB)
参考文献

3,4,5-Tricaffeoylquinic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4736 mL 7.3682 mL 14.7364 mL 36.8411 mL
5 mM 0.2947 mL 1.4736 mL 2.9473 mL 7.3682 mL
10 mM 0.1474 mL 0.7368 mL 1.4736 mL 3.6841 mL
15 mM 0.0982 mL 0.4912 mL 0.9824 mL 2.4561 mL
20 mM 0.0737 mL 0.3684 mL 0.7368 mL 1.8421 mL
25 mM 0.0589 mL 0.2947 mL 0.5895 mL 1.4736 mL
30 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2280 mL
40 mM 0.0368 mL 0.1842 mL 0.3684 mL 0.9210 mL
50 mM 0.0295 mL 0.1474 mL 0.2947 mL 0.7368 mL
60 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4,5-Tricaffeoylquinic acid86632-03-33,4,5-triCQA3,4,5-三咖啡酰奎宁酸AktNF-κBPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBinflammatorykeratinocytescytoskeletonchromatinremodelingneuronalbonemorphogeneticagingInhibitorinhibitorinhibit

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