2. Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. DNA Alkylator/Crosslinker Apoptosis Reactive Oxygen Species Drug Metabolite
  4. 4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4 

目录号: HY-117433S 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

4-Hydroperoxy Cyclophosphamide-d4 是 4-Hydroperoxy cyclophosphamide 的氘代物。4-Hydroperoxy cyclophosphamide 是前体 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于死亡受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 有潜力用于淋巴瘤和自身免疫性疾病的研究。

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4-Hydroperoxy Cyclophosphamide-d<sub>4</sub> Chemical Structure

4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure

CAS No. : 1246816-71-6

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规格 价格 是否有货 数量
1 mg ￥9500
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of 4-Hydroperoxy Cyclophosphamide-d4:

4-Hydroperoxy Cyclophosphamide-d4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-Hydroperoxy Cyclophosphamide-d4 相关抗体:
分子量

297.11

Formula

C7H11D4Cl2N2O4P
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, stored under nitrogen
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (168.29 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3658 mL 16.8288 mL 33.6576 mL
5 mM 0.6732 mL 3.3658 mL 6.7315 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (stored under nitrogen)。-80°C 储存时，请在6个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (270 KB)

产品使用指南 (1538 KB)
参考文献

4-Hydroperoxy Cyclophosphamide-d4 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months (stored under nitrogen)。-80°C 储存时，请在6个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3658 mL 16.8288 mL 33.6576 mL 84.1439 mL
5 mM 0.6732 mL 3.3658 mL 6.7315 mL 16.8288 mL
10 mM 0.3366 mL 1.6829 mL 3.3658 mL 8.4144 mL
15 mM 0.2244 mL 1.1219 mL 2.2438 mL 5.6096 mL
20 mM 0.1683 mL 0.8414 mL 1.6829 mL 4.2072 mL
25 mM 0.1346 mL 0.6732 mL 1.3463 mL 3.3658 mL
30 mM 0.1122 mL 0.5610 mL 1.1219 mL 2.8048 mL
40 mM 0.0841 mL 0.4207 mL 0.8414 mL 2.1036 mL
50 mM 0.0673 mL 0.3366 mL 0.6732 mL 1.6829 mL
60 mM 0.0561 mL 0.2805 mL 0.5610 mL 1.4024 mL
80 mM 0.0421 mL 0.2104 mL 0.4207 mL 1.0518 mL
100 mM 0.0337 mL 0.1683 mL 0.3366 mL 0.8414 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroperoxy Cyclophosphamide-d41246816-71-6DNA Alkylator/CrosslinkerApoptosisReactive Oxygen SpeciesDrug MetaboliteInhibitorinhibitorinhibit

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目录号：
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