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  4. 5-Octyl-α-ketoglutarate

5-Octyl-α-ketoglutarate  (Synonyms: 5-Octyl 2-oxopentanedioate)

目录号: HY-145452
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5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) 是赖氨酸脱甲基酶的底物，具有细胞渗透性。5-Octyl-α-ketoglutarate 与蛋白质去甲基化相关,可抑制 wtCRBN 表达细胞的细胞增殖，并且还增强 Lenalidomide (HY-A0003) 诱导的敏感性，抑制骨髓瘤 (MM) 细胞的耐药性。当骨髓瘤 (MM) 细胞处于谷氨酰胺依赖的增殖过程中，会使谷氨酰胺分解代谢的 α-ketoglutarate 增加来促进蛋白质去甲基化。

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5-Octyl-α-ketoglutarate Chemical Structure

5-Octyl-α-ketoglutarate Chemical Structure

CAS No. : 1616344-00-3

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5-Octyl-α-ketoglutarate 相关抗体

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生物活性

5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1].

分子量

258.31

Formula

C13H22O5
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
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5-Octyl-α-ketoglutarate 相关分类

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Keywords:

5-Octyl-α-ketoglutarate1616344-00-35-Octyl 2-oxopentanedioateOthersMyelomaMMcell-permeablelenalidomidewtCRBNproliferationInhibitorinhibitorinhibit

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