2. Neuronal Signaling
  3. Calcineurin
  4. 6,4'-Dihydroxy-7-methoxyflavanone

6,4'-Dihydroxy-7-methoxyflavanone 

目录号: HY-N9736
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摩尔计算器

6,4'-Dihydroxy-7-methoxyflavanone 是一种黄酮类化合物，是可以从心材 Dalbergia odorifera 中分离得到的天然产物。6,4'-DiHydroxy-7-methoxyflavanone 抑制核因子 kappa-B 配体 (RANKL) 受体激活剂诱导的破骨细胞生成。6,4'-Dihydroxy-7-methoxyflavanone 具有抗氧化、抗炎和神经保护作用。6,4'-Dihydroxy-7-methoxyflavanone 可用于骨质疏松症的研究。

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6,4'-Dihydroxy-7-methoxyflavanone Chemical Structure

6,4'-Dihydroxy-7-methoxyflavanone Chemical Structure

CAS No. : 189689-32-5

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6,4'-Dihydroxy-7-methoxyflavanone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis[1].

体外研究
(In Vitro)

6,4'-Dihydroxy-7-methoxyflavanone（3-30 µM；巨噬细胞）以剂量依赖性方式抑制破骨细胞生成和 TRAP 活性[1]。
6,4'-Dihydroxy-7-methoxyflavanone（0-30 µM；48 小时）会破坏成熟破骨细胞的肌动蛋白环形成[1]。
6,4'-Dihydroxy-7-methoxyflavanone（0-30 µM；1 小时；巨噬细胞）通过抑制作用抑制 RANKL 诱导的活化 T 细胞核因子、细胞质、钙调神经磷酸酶依赖性 1 (NFATc1) 和 c-Fos 的表达丝裂原激活蛋白激酶 (MAPK) 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6,4'-Dihydroxy-7-methoxyflavanone 相关抗体:

Western Blot Analysis[1]

Cell Line: Macrophages
Concentration: 0, 1, 3, 10, and 30 µM
Incubation Time: 1 hours
Result: Inhibited RANKL-induced phosphorylation of JNK without decrease of the phosphorylation of ERK and p38 MAPK.
分子量

286.28

Formula

C16H14O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6,4'-Dihydroxy-7-methoxyflavanone 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

6,4'-Dihydroxy-7-methoxyflavanone189689-32-5CalcineurinPP2BPPP3flavonoidnature productDalbergia odoriferaosteoclastogenesisantioxidantanti-inflammatoryneuroprotectiveInhibitorinhibitorinhibit

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