2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC Endogenous Metabolite
  4. Butyric acid

Butyric acid  (Synonyms: Butanoic acid)

目录号: HY-B0350
COA 产品使用指南

摩尔计算器

Butyric acid 是一种 HDAC 抑制剂，具有抗肿瘤活性。

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Butyric acid Chemical Structure

Butyric acid Chemical Structure

CAS No. : 107-92-6

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Butyric acid 的其他形式现货产品:

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Other Forms of Butyric acid:

Butyric acid 相关抗体

Top Publications Citing Use of Products

    Butyric acid purchased from MCE. Usage Cited in: Neurobiol Dis. 2017 Dec 14;111:12-25.  [Abstract]

    Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

    IC50 & Target

    HDAC

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    体外研究
    (In Vitro)

    Butyric acid is a HDAC inhibitor[1]. Butyric acid induces morphological changes, inhibits cell proliferation and impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- and time-dependent decrease in cell viability, in both 5-8F and 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition and disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate[2]. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR and PCNA protein. Sodium butyrate dose-dependently induces cell cycle arrest in G0/G1 phase and reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, and pro-apoptosis bak genes, and protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, and Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), and the levels of cyclin D1 and CDK6 are reduced by 5 and 10 mM butyrate[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Butyric acid 相关抗体:
    体内研究
    (In Vivo)

    Sodium Butyrate (300 mg/kg, s.c.) provides almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia[3]. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    88.11

    Formula

    C4H8O2
    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    中文名称

    丁酸
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    纯度 & 产品资料

    纯度: ≥99.0%

    COA (187 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [2]

    Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL DMSO, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Rats[3]
    Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Butyric acid 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Butyric acid107-92-6Butanoic acid丁酸HDACEndogenous MetaboliteHistone deacetylasesInhibitorinhibitorinhibit

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    目录号：
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