2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. Nucleoside Antimetabolite/Analog Drug Metabolite Apoptosis DNA/RNA Synthesis
  4. CNDAC

CNDAC 是可口服试剂 Sapacitabine (HY-16445) 的代谢物，为核苷酸类似物。CNDAC 诱导 DNA 损伤和凋亡 (apoptosis)。

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CNDAC Chemical Structure

CNDAC Chemical Structure

CAS No. : 135598-68-4

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CNDAC 的其他形式现货产品:

Other Forms of CNDAC:

CNDAC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis[1][2].

体外研究
(In Vitro)

CNDAC 有一个独特的作用机制: 进入 DNA 后，它诱导单链断裂 (SSBs)，当细胞经历第二个 S 期时，单链断裂 (SSBs) 转化为双链断裂 (DSBs)[1]。
缺乏 Rad51D 和 XRCC3 可使细胞对 CNDAC (0-1 μM; 24 h) 敏感[1]。
CNDAC (0-100 μM; 3 days) 抑制 HL-60 和 THP-1 细胞的增殖[2]。
CNDAC (0-10 μM; 3-6 days) 诱导 HL-60 和 THP-1 细胞的凋亡[2]。
CNDAC (6 μM; 48 h) 诱导 HCT116 细胞在延迟 S 期后的 G2 期停止细胞周期[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CNDAC 相关抗体:

Cell Viability Assay[1]

Cell Line: Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0-100 μM
Incubation Time: 3 days
Result: Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis[2]

Cell Line: HL-60 and THP-1 cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time: 3, 4, 5, and 6 days
Result: Induced apoptosis in both cells.

Cell Cycle Analysis[3]

Cell Line: HCT116
Concentration: 6 μM
Incubation Time: 48 h
Result: 36 and 36% of cells were arrested in late-S and G2/M phases, respectively.
体内研究
(In Vivo)

CNDAC (20mg/kg; i.p.; daily for 10 days) 显示小鼠抗肿瘤活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CDF1 mice, P388 tumor model[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, daily for 10 days
Result: Greatly increased the survival time and survival rate.
分子量

252.23

Formula

C10H12N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CNDAC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNDAC135598-68-4Nucleoside Antimetabolite/AnalogDrug MetaboliteApoptosisDNA/RNA Synthesisacute myelogenous leukemiaAMLCHOHL-60THP-1Inhibitorinhibitorinhibit

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目录号：
HY-16445A
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