2. Metabolic Enzyme/Protease Apoptosis
  3. HIF/HIF Prolyl-Hydroxylase Apoptosis
  4. EL-102

EL-102 是 hypoxia-induced factor 1 (Hif1α) 的抑制剂。EL-102 诱导细胞凋亡，抑制微管蛋白聚合，并显示抗前列腺癌活性。EL-102 可用于癌症的研究。

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EL-102 Chemical Structure

EL-102 Chemical Structure

CAS No. : 1233948-61-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2368
In-stock
1 mg ￥1100
In-stock
5 mg ￥2800
In-stock
10 mg ￥4500
In-stock
50 mg ￥9500
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

EL-102 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer[1].

IC50 & Target

IC50: 24 nM (CWR22), 21.7 nM (22Rv1), 40.3 nM (DU145), 37.0 nM (PC-3), 14.4 nM (DLKP), 16.3 nM (DLKPA)[1]
体外研究
(In Vitro)

EL-102 (0-120 nM; 72 h) inhibits prostate cancer cells proliferation in vitro[1].
EL-102 (0-100 nM; 72 h) shows cytotoxicity to prostate cancer cell lines[1].
EL-102 (10-100 nM; 24-72 h) induces cellular apoptosis and affects cell cycle[1].
EL-102 (10-100 nM; 24-48 h) affects PARP cleavage in DU145 cells[1].
EL-102 (5 nM; 0-60 min) inhibits tubulin polymerisation activity[1].
EL-102 (0-100 nM; 1 hour) inhibits Hif1α protein expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EL-102 相关抗体:

Cell Proliferation Assay[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 0-120 nM
Incubation Time: 72 hours
Result: Inhibited proliferation of CWR22, 22Rv1, DU145, PC-3, DLKP and doxorubicin-selected variant DLKPA cells with IC50s of 24, 21.7, 40.3, 37.0, 14.4 and 16.3 nM, respectively.

Cell Cytotoxicity Assay[1]

Cell Line: CWR22, 22Rv1, DU145 and PC-3 cell lines
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Exibited cytotoxicity to prostate cancer cell lines, and showed no additive effect on the inhibition of cell viability with docetaxel.

Apoptosis Analysis[1]

Cell Line: CWR22, 22Rv1, DU145, PC-3, DLKP and DLKPA cell lines
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Induced cell apoptosis to inhibits cell viability with a dose of 100 nM.

Western Blot Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24 and 48 hours
Result: Increased PARP cleavage in DU145 cells and showed a more dramatic effect with docetaxel adding.

Cell Cycle Analysis[1]

Cell Line: DU145 cell line
Concentration: 10 and 100 nM
Incubation Time: 24, 48 and 72 hours
Result: Increased loss of cells from G1 phase and accumulated cells in G2/M phase.

Western Blot Analysis[1]

Cell Line: Prostate cancer cells
Concentration: 10 , 50 and 100 nM
Incubation Time: 24 and 48 hours
Result: Modestly inhibited Hif1α expression at doses of 50 and 100 nM in normoxia.
体内研究
(In Vivo)

EL-102 (12 and 15 mg/kg; p.o. 5-day on and 2-day off, from 13 to 37 days after tumour transplantation) potentiates effects of docetaxel in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with CWR22 xenografts[1]
Dosage: 12 and 15 mg/kg
Administration: Oral gavage; 12 and 15 mg/kg 5-day on and 2-day off; from 13 to 37 days after tumour transplantation
Result: Showed no effect on tumor growth, but enhanced the effect of docetaxel on tumor .
分子量

384.47

Formula

C19H16N2O3S2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 36 mg/mL (93.64 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6010 mL 13.0049 mL 26.0098 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

EL-102 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6010 mL 13.0049 mL 26.0098 mL 65.0246 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL 13.0049 mL
10 mM 0.2601 mL 1.3005 mL 2.6010 mL 6.5025 mL
15 mM 0.1734 mL 0.8670 mL 1.7340 mL 4.3350 mL
20 mM 0.1300 mL 0.6502 mL 1.3005 mL 3.2512 mL
25 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6010 mL
30 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1675 mL
40 mM 0.0650 mL 0.3251 mL 0.6502 mL 1.6256 mL
50 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3005 mL
60 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0837 mL
80 mM 0.0325 mL 0.1626 mL 0.3251 mL 0.8128 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EL-1021233948-61-2EL102EL 102HIF/HIF Prolyl-HydroxylaseApoptosisHypoxia-inducible factorsHIFsHIF-PHtoluidinesulphonamidetaxanesdocetaxelPC-3DU14522Rv1CWR22cancerInhibitorinhibitorinhibit

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HY-16187
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