ROCK Inhibitors

ROCK

ROCK1

ROCK2

ROCK Inhibitors & Activators

Product Name	ROCK	ROCK1	ROCK2	Purity
Y-27632		ROCK-I, Ki: 220 nM	ROCK-II, Ki: 300 nM	99.91%
Y-27632 dihydrochloride		ROCK-I, Ki: 220 nM	ROCK-II, Ki: 300 nM	99.98%
Chroman 1		ROCK1, IC₅₀: 52 pM	ROCK2, IC₅₀: 1 pM	99.42%
Belumosudil		ROCK1, IC₅₀: 24 μM	ROCK2, IC₅₀: 105 nM	99.77%
Fasudil Hydrochloride		p160ROCK, Ki: 0.33 μM	ROCK2, IC₅₀: 0.158 μM	99.96%
Verosudil hydrochloride		ROCK1, Ki: 2 nM	ROCK2, Ki: 2 nM
DJ4		ROCK1, IC₅₀: 5 nM	ROCK2, IC₅₀: 50 nM	98.48%
Thiazovivin	ROCK			99.94%
Narciclasine	ROCK			99.88%
Afuresertib	ROCK, IC₅₀: 100 nM			99.54%
GSK269962A		ROCK1, IC₅₀: 1.6 nM	ROCK2, IC₅₀: 4 nM	99.83%
GSK429286A		ROCK1, IC₅₀: 14 nM		98.17%
H-1152 dihydrochloride			ROCKII, IC₅₀: 12 nM	99.09%
Ripasudil		ROCK1, IC₅₀: 51 nM	ROCK2, IC₅₀: 19 nM	99.92%
Y-33075	ROCK, IC₅₀: 3.6 nM			99.19%
Pentanoic acid	ROCK			≥98.0%
ROCK inhibitor-2		ROCK1, IC₅₀: 17 nM	ROCK2, IC₅₀: 2 nM	99.92%
CMPD101			ROCK2, IC₅₀: 1.4 μM	98.95%
SAR407899		ROCK-1, IC₅₀: 276 nM	ROCK-2, IC₅₀: 102 nM	99.60%
AT13148		ROCKI, IC₅₀: 6 nM	ROCKII, IC₅₀: 4 nM	99.21%
RKI-1447		ROCK1, IC₅₀: 14.5 nM	ROCK2, IC₅₀: 6.2 nM	98.29%
Y-33075 dihydrochloride	ROCK, IC₅₀: 3.6 nM			98.02%
SR-3677		ROCK-I, IC₅₀: 56 nM	ROCK-II, IC₅₀: 3 nM	99.90%
Afuresertib hydrochloride	ROCK, IC₅₀: 100 nM			99.95%
LX7101			ROCK2, IC₅₀: 10 nM	99.75%
GSK180736A		ROCK1, IC₅₀: 100 nM		98.01%
CRT0066854			ROCK2, IC₅₀: 620 nM	99.59%
H-1152			ROCKII, IC₅₀: 12 nM	98.63%
Hydroxyfasudil		ROCK1, IC₅₀: 0.73 μM	ROCK2, IC₅₀: 0.72 μM	98.42%
SAR407899 hydrochloride		ROCK-1, IC₅₀: 276 nM	ROCK-2, IC₅₀: 102 nM	98.66%
SB-772077B dihydrochloride		ROCK1, IC₅₀: 5.6 nM	ROCK2, IC₅₀: 6 nM	≥99.0%
BAY-549		ROCK-1, IC₅₀: 0.6 nM	ROCK-2, IC₅₀: 1.1 nM	99.46%
BDP5290		ROCK1, IC₅₀: 5 nM	ROCK2, IC₅₀: 50 nM	98.80%
Rho-Kinase-IN-1		ROCK1, Ki: 30.5 nM	ROCK2, Ki: 3.9 nM	99.91%
Belumosudil mesylate		ROCK1, IC₅₀: 24 μM	ROCK2, IC₅₀: 105 nM	99.89%
GSK-25		ROCK1, IC₅₀: 7 nM		99.68%
Rho-Kinase-IN-2			ROCK2, IC₅₀: 3 nM	99.29%
Sovesudil		ROCK-I, IC₅₀: 3.7 nM	ROCK-II, IC₅₀: 2.3 nM	98.31%
Verosudil		ROCK1, Ki: 2 nM	ROCK2, Ki: 2 nM	99.18%
Hydroxyfasudil hydrochloride		ROCK1, IC₅₀: 0.73 μM	ROCK2, IC₅₀: 0.72 μM	98.88%
RKI-1447 dihydrochloride		ROCK1, IC₅₀: 14.5 nM	ROCK2, IC₅₀: 6.2 nM	98.04%
HSD1590		ROCK1, IC₅₀: 1.22 nM	ROCK2, IC₅₀: 0.51 nM	99.54%
ROCK2-IN-2			ROCK2, IC₅₀: 1 μM	98.02%
Sovesudil hydrochloride		ROCK-I, IC₅₀: 3.7 nM	ROCK-II, IC₅₀: 2.3 nM	99.45%
CRT0066854 hydrochloride			ROCKII, IC₅₀: 620 nM	99.29%
ROCK-IN-1			ROCK2, IC₅₀: 1.2 nM	98.17%
Chroman 1 dihydrochloride		ROCK1, IC₅₀: 52 pM	ROCK2, IC₅₀: 1 pM	99.11%
Hu7691		ROCK1, IC₅₀: 354 nM
THK01		ROCK1, IC₅₀: 923 nM	ROCK2, IC₅₀: 5.7 nM	99.80%
LIMK-IN-1		ROCK1, IC₅₀: 260 nM	ROCK2, IC₅₀: 2700 nM	99.33%
RKI-1313		ROCK1, IC₅₀: 34 μM	ROCK2, IC₅₀: 8 μM	98.2%
Fasudil		p160ROCK, Ki: 0.33 μM	ROCK2, IC₅₀: 0.158 μM
Fasudil hydrochloride semihydrate		p160ROCK, Ki: 0.33 μM	ROCK2, IC₅₀: 0.158 μM
Fasudil dihydrochloride		p160ROCK, Ki: 0.33 μM	ROCK2, IC₅₀: 0.158 μM
Hu7691 free base		ROCK1, IC₅₀: 354 nM
SR-3677 dihydrochloride		ROCK-I, IC₅₀: 56 nM	ROCK-II, IC₅₀: 3 nM
ROCK2-IN-9			ROCK2, IC₅₀: 36.8 nM
ROCK2-IN-7			ROCK2
Glycyl H-1152 hydrochloride			ROCKII, IC₅₀: 11.8 nM
GSK269962A hydrochloride		ROCK1, IC₅₀: 1.6 nM	ROCK2, IC₅₀: 4 nM
GSK317354A	ROCK
NRL-1049		ROCK1, IC₅₀: 26 μM	ROCK2, IC₅₀: 0.59 μM
PT-262	ROCK, IC₅₀: 5 μM			99.21%
PF-4950834		ROCK1, IC₅₀: 33.12 nM	ROCK2, IC₅₀: 8.35 nM
ROCK2-IN-5			ROCK2, IC₅₀: 2.13 μM
ROCK-IN-6			ROCK2, IC₅₀: 2.19 nM
HA-100 hydrochloride	ROCK
Ripasudil free base		ROCK1, IC₅₀: 51 nM	ROCK2, IC₅₀: 19 nM
LX7101 monohydrochloride			ROCK2, IC₅₀: 10 nM
CMPD101 hydrochloride			ROCK2, IC₅₀: 1.4 μM

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