2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Valsartan-d9

Valsartan-d9  (Synonyms: 缬沙坦 D9; CGP 48933-d9)

目录号: HY-18204S 纯度: 99.33%
COA 产品使用指南

摩尔计算器

Valsartan-d9 是 Valsartan 氘代化合物。Valsarta 是血管紧张素 II 受体拮抗剂，有潜力用于高血压和心力衰竭的研究。

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Valsartan-d<sub>9</sub> Chemical Structure

Valsartan-d9 Chemical Structure

CAS No. : 1089736-73-1

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规格 价格 是否有货 数量
1 mg ￥2900
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Valsartan-d9:

Valsartan-d9 相关抗体

Top Publications Citing Use of Products

查看 Angiotensin Receptor 亚型特异性产品:

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

IC50 & Target

AT1 Receptor

 

体外研究
(In Vitro)

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Valsartan-d9 相关抗体:
分子量

444.57

Formula

C24H20D9N5O3
CAS 号
性状

固体

颜色

White to yellow

中文名称

缬沙坦 d9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 30 mg/mL (67.48 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

DMF 中的溶解度 : ≥ 30 mg/mL (67.48 mM)

Ethanol 中的溶解度 : ≥ 30 mg/mL (67.48 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2494 mL 11.2468 mL 22.4936 mL
5 mM 0.4499 mL 2.2494 mL 4.4987 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.33%

COA (274 KB) LCMS (95 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[4]

Rats: Rats are randomly divided into two groups: (i) valsartan-treated group that is given intravenously 3 mg/kg/day valsartan in 0.5 mL normal saline via the vein daily for 1 week; (ii) hydralazine-treated group receiving 0.2 mg/kg/day hydralazine injection in saline; and (iii) control group that receives saline injection in the same way (n=15 for each group)[4].

Mice: Valsartan is dissolved in water containing 0.5% methylcellulose solution. Valsartan (5-40 mg/kg/d) is administered by oral (p.o.) route in a volume of 10 mL/kg body weight using the gavage technique. Potential alteration in blood pressure in response to chronic treatment with valsartan is assessed with a commercial blood pressure analysis systemdesigned. The mice are trained for at least 2 consecutive days to adapt to the apparatus before the study is initiated. To record the blood pressure, the mice are placed on a heated pad (35°C) and measured with a programmable tail-cuff sphygmomanometer in steady state. The average of 10 readings from each mouse is recorded[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Valsartan-d9 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / DMF / Ethanol 1 mM 2.2494 mL 11.2468 mL 22.4936 mL 56.2341 mL
5 mM 0.4499 mL 2.2494 mL 4.4987 mL 11.2468 mL
10 mM 0.2249 mL 1.1247 mL 2.2494 mL 5.6234 mL
15 mM 0.1500 mL 0.7498 mL 1.4996 mL 3.7489 mL
20 mM 0.1125 mL 0.5623 mL 1.1247 mL 2.8117 mL
25 mM 0.0900 mL 0.4499 mL 0.8997 mL 2.2494 mL
30 mM 0.0750 mL 0.3749 mL 0.7498 mL 1.8745 mL
40 mM 0.0562 mL 0.2812 mL 0.5623 mL 1.4059 mL
50 mM 0.0450 mL 0.2249 mL 0.4499 mL 1.1247 mL
60 mM 0.0375 mL 0.1874 mL 0.3749 mL 0.9372 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valsartan-d91089736-73-1CGP 48933-d9缬沙坦 d9Angiotensin ReceptorInhibitorinhibitorinhibit

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目录号：
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