2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Vatinoxan hydrochloride

Vatinoxan hydrochloride  (Synonyms: MK-467 hydrochloride; L-659066 hydrochloride)

目录号: HY-19057A 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Vatinoxan hydrochloride (MK-467hydrochloride;L-659066 hydrochloride) 是一种外周 α2 肾上腺素能受体 (α2 adrenergic receptor) 拮抗剂。

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Vatinoxan hydrochloride Chemical Structure

Vatinoxan hydrochloride Chemical Structure

CAS No. : 130466-38-5

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规格 价格 是否有货 数量
1 mg ￥3350
In-stock
5 mg ￥8500
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Vatinoxan hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

IC50 & Target

α adrenergic receptor

 

体内研究
(In Vivo)

Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

454.97

Formula

C20H27ClN4O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (21.98 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1979 mL 10.9897 mL 21.9795 mL
5 mM 0.4396 mL 2.1979 mL 4.3959 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.89%

COA (183 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1][2]

Dogs[1]

Eight dogs receive either dexmedetomidine (10 μg/kg), Vatinoxan (250 μg/kg or dexmedetomidine (10 μg/kg) with increasing doses of Vatinoxan (250 μg/kg, 500 μg/kg and 750 μg/kg). Treatments are given intravenously (i.v.) in a randomized, crossover design with a 14-day ishout period. Systemic hemodynamics and arterial blood gas analyses are recorded at baseline and at intervals up to 90 min after drugs administration[1].

Cats[2]

Cats are administered seven IV treatments are administered at least 2 weeks apart, consisting of dexmedetomidine 12.5 μg/kg (D12.5) and 25 μg/kg (D25), Vatinoxan 300 μg/kg (M300), and D25 combined with 75, 150, 300 and 600 μg/kg of Vatinoxan (D25M 75, D25M150, D25M300 and D25M600, respectively). Heart rates (HR) are recorded via telemetry and sedation assessed with a simple descriptive score and a visual analogue scale prior to treatments and at intervals until 8 hours thereafter[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Vatinoxan hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1979 mL 10.9897 mL 21.9795 mL 54.9487 mL
5 mM 0.4396 mL 2.1979 mL 4.3959 mL 10.9897 mL
10 mM 0.2198 mL 1.0990 mL 2.1979 mL 5.4949 mL
15 mM 0.1465 mL 0.7326 mL 1.4653 mL 3.6632 mL
20 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7474 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vatinoxan130466-38-5MK-467L-659066MK467MK 467L659066L 659066Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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目录号：
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