2. GPCR/G Protein
  3. Adenosine Receptor
  4. A2AR/A2BR antagonist 1

A2AR/A2BR antagonist 1 (compound 7ai) 对A2AR/A2BR 具有双重拮抗作用，对 A2AR 和 A2AR 的 IC50 值分别为 11.2 nM 和 6.4 nM。A2AR/A2BR antagonist 1 可以促进 T 细胞介导的癌细胞死亡。

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A2AR/A2BR antagonist 1 Chemical Structure

A2AR/A2BR antagonist 1 Chemical Structure

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A2AR/A2BR antagonist 1 相关抗体

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查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A2AR/A2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A2AR/A2BR, with the IC50 values of 11.2 nM and 6.4 nM for A2AR and A2BR, respectively. A2AR/A2BR antagonist 1 promotes T cell-mediated cancer cell death[1].

IC50 & Target

A2AR

11.2 nM (IC50)

A2BR

6.4 nM (IC50)

体外研究
(In Vitro)

A2AR/A2BR antagonist 1 (compound 7ai) (0.1, 1, 10 μM, 0-48 h) 可以逆转 NECA (HY-103173) 介导的免疫抑制，促进 OT-I CTL 细胞的激活和杀伤能力，从而发挥抗癌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

A2AR/A2BR antagonist 1 相关抗体:

Western Blot Analysis[1]

Cell Line: Human Jurkat T cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 0-48 h
Result: Almost completely abolished NECA (HY-103173)-induced upregulation of expression of immunosuppressive molecules (PD-1 and TIM-3).
分子量

431.45

Formula

C24H17N9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A2AR/A2BR antagonist 1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A2AR/A2BR antagonist 1Adenosine ReceptorP1 receptorCancerT cellsTumor microenvironmentImmunosuppressive moleculeAdenosineInhibitorinhibitorinhibit

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产品名称：
A2AR/A2BR antagonist 1
目录号：
HY-158057
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