1. Protein Tyrosine Kinase/RTK Antibody-drug Conjugate/ADC Related
  2. c-Met/HGFR ADC Antibody
  3. ABBV-303

ABBV-303 是基于 TriNKET 技术设计而成的、靶向 c-Met 的多特性 NK 细胞抗体,可用于自然杀伤 (NK) 细胞重定向疗法。ABBV-303 抗体由三个功能臂组成,分别是靶向 c-Met 的单链可变片段 (scFV)、靶向 NKG2D 的 Fab 臂,和靶向 NK 细胞 CD16a 的 Fc 片段。

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ABBV-303 Chemical Structure

ABBV-303 Chemical Structure

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     可免费申领三个不同产品的试用装。

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABBV-303 is a multi-specific NK cell antibody targeting c-Met designed based on TriNKET technology for natural killer (NK) cell redirection therapy. The ABBV-303 antibody consists of three functional arms, a single-chain variable fragment (scFV) targeting c-Met, a Fab arm targeting NKG2D, and an Fc fragment targeting NK cell CD16a[1].

体外研究
(In Vitro)

ABBV-303 三个功能臂的详细介绍[1]:
(1) 单链可变片段 (scFV):基于 ABT-700 (HY-P99391) 的 scFV,也是 c-Met 靶向的抗体-药物偶联物 (ADCs) ABBV-400 和 Teliso-V 的共有片段;
(2) Fab 臂:靶向 NKG2D,用于结合表达 NKG2D 的 NK 细胞和活化的 CD8+ T 细胞;
(3) 常规 Fc 片段:异二聚体的 IgG1 Fc,靶向 NK 细胞上的 CD16a,还用于连接 ABBV-303 的其他两个功能臂。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ABBV-303
目录号:
HY-P990306
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