2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE/BChE-IN-1

AChE/BChE-IN-1 是一种有效和可透过血脑屏障的乙酰胆碱酯酶 (Acetylcholinesterase) 和丁酰胆碱酯酶 (Butyrylcholinesterase) 的双重抑制剂，对 hAChE 和 hBChE 的 IC50 值分别为 1.06 和 7.3 nM。AChE/BChE-IN-1 具有抗氧化活性。AChE/BChE-IN-1 可用于研究阿尔茨海默症。

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AChE/BChE-IN-1 Chemical Structure

AChE/BChE-IN-1 Chemical Structure

CAS No. : 2720624-42-8

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AChE/BChE-IN-1 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE/BChE-IN-1 is a potent and brain-penetrant dual inhibitor of Acetylcholinesterase and Butyrylcholinesterase, with IC50s of 1.06 and 7.3 nM for hAChE and hBChE, respectively. AChE/BChE-IN-1 also has antioxidant activity. AChE/BChE-IN-1 can be used for the research of Alzheimer’s disease[1].

IC50 & Target

AChE

 

BChE

 

体外研究
(In Vitro)

AChE/BChE-IN-1 (compound 5i) is notactive against hBACE-1 at the tested concentration (1 μM)[1].
AChE/BChE-IN-1 scavenges the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, with an IC50 of 92.0 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-1 相关抗体:
体内研究
(In Vivo)

AChE/BChE-IN-1 (2 mg/kg; i.p. 3 times per week for 4 weeks) rescues learning and memory impairments, delays the Alzheimer-like pathology progression, improves basal synaptic efficacy, and significantly reduces hippocampal oxidative stress and neuroinflammation in 10 month-old APP/PS1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AβPPswe/PS-1 double transgenic male mice (10 months)[1]
Dosage: 2 mg/kg
Administration: I.p. 3 times per week for 4 weeks
Result: Significantly enhanced learning and memory.
Reduced Aβ42/Aβ40 ratio in the hippocampus.
Increased the strength of synaptic transmission, without affecting long-term potentiation (LTP).
Decreased the levels of oxidative stress and neuroinflammation markers in the hippocampus.
分子量

587.11

Formula

C32H35ClN6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE/BChE-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-12720624-42-8Cholinesterase (ChE)dualAcetylcholinesteraseButyrylcholinesterasehAChEhBChEantioxidantAlzheimerInhibitorinhibitorinhibit

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