1. Anti-infection
  2. SARS-CoV
  3. Adintrevimab

Adintrevimab  (Synonyms: ADG 20)

目录号: HY-P99423 纯度: 96.94%
COA

Adintrevimab (ADG 20) 是一种人 IgG1 单克隆 SARS-CoV (SARS-CoV) 抗体。Adintrevimab 抑制 SARS-CoV-2 变体和其他具有大流行潜力的 SARS 样冠状病毒。

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Adintrevimab Chemical Structure

Adintrevimab Chemical Structure

CAS No. : 2516243-54-0

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5 mg ¥7800
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].

同型

Human IgG1 lambda1

推荐同型对照抗体
体外研究
(In Vitro)

Adintrevimab 的 Fc 片段区域经过修饰以延长其半衰期。 Adintrevimab 与 SARS-CoV-2 刺突糖蛋白受体结合域中的一个独特表位结合,该表位与血管紧张素转换酶 2 结合位点部分重叠,在 sarbecoviruses 中高度保守。在体外,Adintrevimab 已证明对 SARS-CoV-2(包括 Alpha、Beta、Gamma 和 Delta)的大多数变体和亚系以及其他 SARS 样病毒具有有效的中和活性。Adintrevimab 对 Omicron BA.1/BA.1.1 的体外活性降低,对 BA.2、BA.3、BA.4 和 BA.5 缺乏活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Adintrevimab(9.25、55、333 或 2,000μg;腹腔注射;一次)以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]
Adintrevimab(5-25mg/kg;静脉注射;一次)以剂量依赖性方式提供针对 SARS-CoV-2/WA1/2020 感染的保护[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg)
Administration: Intraperitoneal injection; single dose
Result: Showed significant reduction in lung viral load and virus-induced lung pathology.
Animal Model: Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 5 mg/kg, 25 mg/kg
Administration: Intravenous injection; single dose
Result: Reduced pulmonary inflammation.
Clinical Trial
CAS 号
Unlabeled Cas

性状

液体

颜色

Colorless to light yellow

中文名称

艾定韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Adintrevimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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