2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 

目录号: HY-P5372
产品使用指南

摩尔计算器

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 是一种有生物活性的肽。(蛋白酶激活受体 1 (PAR-1) 属于 G 蛋白偶联受体亚家族，已知可介导凝血酶的细胞作用。该肽是 PAR-1 选择性激动剂，对 PAR-1 的特异性高于 PAR-2。使用 HEK293 细胞在基于细胞的钙信号传导测定中评估肽的特异性。 PAR-1 选择性激动剂可用于研究 PAR-1 体内激活。除了凝血酶的多种细胞作用外，PAR-1 还被证明可以与 PAR-4 协调并调节凝血酶诱导的肝细胞癌，该肝细胞癌在肿瘤环境中形成凝血酶，被归类为“凝血型”。)

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Custom Peptide Synthesis

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Chemical Structure

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Chemical Structure

CAS No. : 211190-38-4

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规格 是否有货
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

分子量

883.02

Formula

C42H63FN12O8
CAS 号
Sequence

Ala-{Phe(p-Fluoro)}-Arg-{Cha}-{Cit}-Tyr-NH2
Sequence Shortening

A-{Phe(p-Fluoro)}-R-{Cha}-{Cit}-Y-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2211190-38-4Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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