1. Anti-infection Cytoskeleton Cell Cycle/DNA Damage Autophagy Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  2. Parasite Microtubule/Tubulin Autophagy Apoptosis Reactive Oxygen Species VEGFR HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial
  3. Albendazole

Albendazole  (Synonyms: 阿苯达唑; SKF-62979)

目录号: HY-B0223 纯度: 99.00%
COA 产品使用指南

Albendazole (SKF-62979) 是一种口服有效的广谱的抗寄生虫剂,具有高效、低宿主毒性的特点,可用于人类和动物胃肠道寄生虫的研究。Albendazole 可诱导癌细胞的凋亡和自噬,并抗细胞增殖和抑制细胞周期进程。Albendazole 还能抑制微管蛋白的聚合和 HIF-1αVEGF 的表达,具有抗氧化活性,能抑制癌细胞的糖酵解过程。

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Albendazole Chemical Structure

Albendazole Chemical Structure

CAS No. : 54965-21-8

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10 mM * 1 mL in DMSO ¥550
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100 mg ¥500
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500 mg ¥800
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

IC50 & Target

parasites, tubulin[1][2].
HIF-1α, VEGF[3].

体外研究
(In Vitro)

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner[1].
? Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle[1].
? Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner[2].
? Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells[2].
? Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKHEP-1 cells
Concentration: 100, 500, 1000 nM
Incubation Time: 1, 3, or 5 days
Result: Inhibited cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: SKHEP-1 HCC cells
Concentration: 100, 250, 500, 1000 nM
Incubation Time: 3 days
Result: Showed dose-dependent effect on the cell cycle kinetics.

Apoptosis Analysis[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 24, 36 h
Result: Promoted apoptosis in colon cancer cells.

Cell Autophagy Assay[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 24, 36 h
Result: Induced autophagy in colon cancer cells.

Western Blot Analysis[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 12, 24, 36 h
Result: Induced apoptosis-related protein (PARP, caspase-3) and autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in a time-dependent manner.
Increased phosphorylation of different MAPKs (AMPK, ERK, JNK, p38) and ULK1 protein in a time dependent manner, and up-regulated the activation of different MAPKs.
Caused the activation of both MAPK and AMPK pathways.

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 500 nM
Incubation Time: 24 h
Result: Inhibited hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.
体内研究
(In Vivo)

Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice[4].
? Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (10-week-age; Echinococcus granulosus infection model)[4].
Dosage: 10 mg/kg
Administration: Oral gavage; once a day for 30 days.
Result: Reduced Echinococcus granulosus cyst weights.
Animal Model: Male BALB/c Nu/Nu mice (6 to 10-week-old; inoculated subcutaneously with SKHEP-1)[1].
Dosage: 50, 150, 300 mg/kg
Administration: Oral administration; per day in two divided dose for 20 days.
Result: Profoundly suppressed tumor growth in vivo.
Clinical Trial
分子量

265.33

Formula

C12H15N3O2S

CAS 号
性状

固体

颜色

White to off-white

中文名称

阿苯达唑;丙硫达唑;丙硫咪唑;抗蠕敏;扑尔虫;肠虫清

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 1 year
-20°C 6 months
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 20 mg/mL (75.38 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7689 mL 18.8445 mL 37.6889 mL
5 mM 0.7538 mL 3.7689 mL 7.5378 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 1 year; -20°C, 6 months。-80°C储存时,请在1个月内使用, -20°C储存时,请在6个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2 mg/mL (7.54 mM); 悬浊液; 超声助溶

    此方案可获得 2 mg/mL的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;再向上述体系中加入 50 μL Tween-80,混合均匀;然后再继续加入 450 μL 生理盐水 定容至 1 mL

    生理盐水的配制:将 0.9 g 氯化钠,溶解于 ddH₂O 并定容至 100 mL,可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂: 10% DMSO    90% Corn Oil

    Solubility: ≥ 2 mg/mL (7.54 mM); 澄清溶液

    此方案可获得 ≥ 2 mg/mL(饱和度未知)的澄清溶液,此方案实验周期在半个月以上的动物实验酌情使用。

    1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
请输入您的动物体内配方组成:
%
DMSO +
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠,建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括:DMSO ,均可在 MCE 网站选购。 Tween 80,均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO(母液浓度为 mg/mL)。
您所需的储备液浓度超过该产品的实测溶解度,以下方案仅供参考,如有需要,请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液,加入 μL  μL ,混合均匀至澄清,再加 μL Tween 80,混合均匀至澄清,再加 μL 生理盐水
连续给药周期超过半月以上,请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态,从左到右依次添加助溶剂。您可采用超声加热 (超声清洗仪,建议频次 20-40 kHz),涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.00%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 1 year; -20°C, 6 months。-80°C储存时,请在1个月内使用, -20°C储存时,请在6个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7689 mL 18.8445 mL 37.6889 mL 94.2223 mL
5 mM 0.7538 mL 3.7689 mL 7.5378 mL 18.8445 mL
10 mM 0.3769 mL 1.8844 mL 3.7689 mL 9.4222 mL
15 mM 0.2513 mL 1.2563 mL 2.5126 mL 6.2815 mL
20 mM 0.1884 mL 0.9422 mL 1.8844 mL 4.7111 mL
25 mM 0.1508 mL 0.7538 mL 1.5076 mL 3.7689 mL
30 mM 0.1256 mL 0.6281 mL 1.2563 mL 3.1407 mL
40 mM 0.0942 mL 0.4711 mL 0.9422 mL 2.3556 mL
50 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8844 mL
60 mM 0.0628 mL 0.3141 mL 0.6281 mL 1.5704 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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