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  3. Anagyrine hydrochloride

Anagyrine hydrochloride  (Synonyms: (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride)

目录号: HY-121027A
产品使用指南

Anagyrine ((-)-Anagyrine) hydrochloride 是一种存在于 Lupinus albus 中的喹啉类生物碱。Anagyrine hydrochloride 可与毒蕈碱和烟碱乙酰胆碱受体 (AChR) 结合,IC50 值分别为 132 和 2096 µM。Anagyrine hydrochloride 是一种有效的 nAChR 脱敏剂,Anagyrine hydrochloride 可以直接脱敏 nAChR,不需要代谢。

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Anagyrine hydrochloride Chemical Structure

Anagyrine hydrochloride Chemical Structure

CAS No. : 74195-83-8

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Anagyrine hydrochloride 的其他形式现货产品:

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  • 参考文献

生物活性

Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].

体外研究
(In Vitro)

Anagyrine 在 SH-SY5Y 和 TE-671 两种细胞系中均充当部分激动剂, EC50 值分别为 4.2 和 231 μM。 Anagyrine 是 nAChR 的脱敏剂,在 SH-SY5Y 和 TE-671 细胞中的 DC50 值分别为 6.9 和 139 μM[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

280.79

Formula

C15H21ClN2O

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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