1. JAK/STAT Signaling Stem Cell/Wnt
  2. STAT
  3. Angoline hydrochloride

Angoline hydrochloride 是一种有效的、选择性的 IL6/STAT3 信号通路抑制剂,IC50 为 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达,并抑制癌细胞增殖。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Angoline hydrochloride Chemical Structure

Angoline hydrochloride Chemical Structure

CAS No. : 1071676-04-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Angoline hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Angoline hydrochloride:

查看 STAT 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

IC50 & Target

IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)[1]

体外研究
(In Vitro)

Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, >100 and >100 μM, respectively[1].
Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3[1].
Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HepG2/STAT3 cell lines
Concentration: 0, 1, 10, 30 and 100 μM
Incubation Time: 2 hours
Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231, H4 and HepG2 cell lines
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.
分子量

415.87

Formula

C22H22ClNO5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Angoline hydrochloride
目录号:
HY-N7674A
需求量: