2. Anti-infection Neuronal Signaling GPCR/G Protein
  3. Antibiotic Cholecystokinin Receptor
  4. Anthramycin

Anthramycin 是一种有效的抗生素 (antibiotic)，属于苯并二氮杂卓 (PBD) 家族。Anthramycin 具有强大的抗肿瘤 (antitumor) 活性。在小鼠中枢神经系统中，Anthramycin 可作为胆收缩素 (cholecystokinin) 的有效拮抗剂。

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Anthramycin Chemical Structure

Anthramycin Chemical Structure

CAS No. : 4803-27-4

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Anthramycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice[1][2][3].

体外研究
(In Vitro)

ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anthramycin 相关抗体:
体内研究
(In Vivo)

Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice[2].
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (20 ± 2 g, 12-14 each group)[2]
Dosage: 0, 0.3, and 0.5 mg/kg
Administration: IP, once, 10 min before the intracisternal (i.c.) injection of CCK
Result: Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
Animal Model: Female CFN Gif rats (140-180 g)[3]
Dosage: 0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
Administration: SC, daily for 8 days
Result: Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
分子量

315.32

Formula

C16H17N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anthramycin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anthramycin4803-27-4AntibioticCholecystokinin ReceptorCCK ReceptorPyrolobenzodiazepineantibioticcholecystokininantitumorbenzodiazepineInhibitorinhibitorinhibit

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