2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Antitumor agent-73

Antitumor agent-73 是 Diosgenin (HY-N0177) 的衍生物，能够抑制 STAT3 信号通路，外源激活 Pdia3/ERp57。Antitumor agent-73 对多种癌细胞具有强抗肿瘤活性，且是 Diosgenin 的 7.9 -341.7 倍。

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Antitumor agent-73 Chemical Structure

Antitumor agent-73 Chemical Structure

CAS No. : 2812356-72-0

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Antitumor agent-73 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin[1].

IC50 & Target

STAT3

 

体外研究
(In Vitro)

Antitumor agent-73 (compound 2.2f) shows anti-proliferative activity against cancer cells with IC50s of 0.1847 μM (Aspc-1), 4.038 μM (H358), 4.001 μM (HCT116), 0.4483 μM (SW620), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-73 相关抗体:
分子量

858.06

Formula

C50H82BrO4P
CAS 号
Unlabeled Cas

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-73 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-732812356-72-0Antitumor agent73Antitumor agent 73STATDiosgeninderivativeSTAT3Pdia3/ERp57antitumorAspc-1H358HCT116SW620Inhibitorinhibitorinhibit

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