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  4. Antitumor agent-75

Antitumor agent-75 是一种新型有效的抗肿瘤剂。Antitumor agent-75 对癌症和正常人类细胞系具有细胞毒性作用。Antitumor agent-75 与 Antitumor agent-74.html" class="link-product" target="_blank">Antitumor agent-74 (HY-151292) 结合使用时对人肺腺癌（细胞系 A549 ）具有高度选择性的细胞毒作用，其 IC50 值为 2.8 μM。Antitumor agent-75 可用于癌症的研究。

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Antitumor agent-75 Chemical Structure

Antitumor agent-75 Chemical Structure

CAS No. : 2827065-29-0

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Antitumor agent-75 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-75 is a novel potent antitumor agent. Antitumor agent-75 has cytotoxic effects on cancer and normal human cell lines. Antitumor agent-75 shows a highly selective cytotoxic effect against human lung adenocarcinoma (cell line A549) when combined with Antitumor agent-74.html" class="link-product" target="_blank">Antitumor agent-74 (HY-151292), the IC50 value of 2.8 μM. Antitumor agent-75 can be used for the research of cancer[1].

IC50 & Target

IC50: 2.8 μM (A549 cells)[1]
体外研究
(In Vitro)

Antitumor agent-75 (14da) shows a highly selective cytotoxic effect (combined with 13da, mrBIQ 13da/14da) against human lung adenocarcinoma (cell line A549) with an IC50 value of 2.8 μM[1].
Antitumor agent-75 (1, 5, 25, 50, 100μM; 0-48 h) (mriBIQ 13da/14da) has the cytotoxic effect in A549 cells[1].
Antitumor agent-75 (1, 2.5, and 5 μM; 12 h) (mriBIQ 13da/14da) has the mechanism of the cytotoxic effect on A549 cells may be associated with the stopping of the cell cycle in phase S and inhibition of DNA synthesis as well as with the induction of mithochondrial apoptosis[1].
Antitumor agent-75 (1, 2.5 and 5 μM) increases the production of reactive oxygen species (ROS) and induces mitochondrial apoptosis in A549 cells.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-75 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: seven cancer cell lines and WI38 (the Normal Human Fetal Lung Fibroblast line)
Concentration: 1-100 μM
Incubation Time:
Result: Exhibited greater activity against most of the cancer lines and normal human cell lines.

Cell Proliferation Assay[1]

Cell Line: A549 Cell
Concentration: 1, 5, 25, 50, 100 μM
Incubation Time: 0-48 h
Result: Lead to a sharp decrease the presence of mriBIQ 13da/14da at concentrations close to the IC50 values in the rate of cell division.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1, 2.5, and 5 μM
Incubation Time: 12 h
Result: Increased the number of cells in the S-phase with mnBIQ 13da/14da at concentrations of 1, 2.5, and 5 μM at 49.0%, 66.3%, and 68.0%, respectively.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 1, 2.5 and 5 μM
Incubation Time:
Result: (mrBIQ 13da/14da) Induced mitochondrial apoptosis in A549 cells.
分子量

438.50

Formula

C26H23FN6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-75 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-752827065-29-0Antitumor agent75Antitumor agent 75OthersantitumorcytotoxiccancerA549 cellsInhibitorinhibitorinhibit

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目录号：
HY-151295
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