2. Membrane Transporter/Ion Channel Apoptosis
  3. ATP Synthase Apoptosis
  4. Apoptolidin

Apoptolidin 是从 Nocardiopsis 细菌中分离得到的一种聚酮类化合物。Apoptolidin 是一种选择性线粒体 F1FO ATPase 抑制剂。Apoptolidin 是一种凋亡 (apoptosis)诱导剂，可诱导腺病毒型 12 癌基因(包括ElA) (IC50=10-17 ng/ml) 转化的细胞凋亡，但不诱导正常细胞的凋亡。

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Apoptolidin Chemical Structure

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

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规格 价格 是否有货 数量
100 μg ￥6500
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Apoptolidin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

体外研究
(In Vitro)

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptolidin 相关抗体:
分子量

1129.37

Formula

C58H96O21
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

Nocardiopsis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (176 KB)

产品使用指南 (1538 KB)
参考文献

Apoptolidin 相关分类

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Keywords:

Apoptolidin194874-06-1ATP SynthaseApoptosispolyketideF0F1-ATPasecancerapoptoticRG-E1A-7RG-E1A19K-2RG-E1A54K-9RG-E1-4Inhibitorinhibitorinhibit

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