2. Inhibitory Antibodies
  3. Atacicept

Atacicept  (Synonyms: 阿塞西普; TACI-Ig; TACI-Fc 5)

目录号: HY-P99446 纯度: 99.50%
COA

摩尔计算器

Atacicept (TACI-Ig) 是一种重组融合蛋白，包含 TACI 受体的细胞外配体结合部分和人 IgG 的 Fc 部分。Atacicept 通过结合 B 淋巴细胞刺激剂和增殖诱导配体抑制 B 细胞刺激。Atacicept 可用于 B 细胞自身免疫性疾病的研究。

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Atacicept Chemical Structure

Atacicept Chemical Structure

CAS No. : 845264-92-8

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1 mg ￥6800
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Atacicept 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2].

体内研究
(In Vivo)

Atacicept (TACI-Ig; 100 μg; i.p.; 每周三次，共 14 天; BALB/c 小鼠) 降低正常小鼠成熟 B 细胞计数和血清抗体水平[1]。
Atacicept (100 μg; i.p.; 每周三次，共 21 天) 抑制胶原诱导性关节炎 (CIA) 小鼠模型的疾病进展和自身抗体滴度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1 mice with CIA models[1]
Dosage: 100 μg
Administration: intraperitoneal injection; three times of week for 21 days
Result: Increased serum titers of anti-collagen Abs and few overt signs of disease.
Animal Model: BALB/c mice[1]
Dosage: 100 μg
Administration: intraperitoneal injection; three times of week for 14 days
Result: Reduced mature B cell populations but had little effect on other cell lineages.
Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.
Decerased the serum levels of IgM about 2.3-fold.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿塞西普
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.50%

COA (172 KB) SDS-PAGE (68 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atacicept845264-92-8TACI-Ig TACI-Fc 5阿塞西普Othersrecombinant fusion proteinTACI receptorFc IgGB cellautoimmuneInhibitorinhibitorinhibit

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