2. NF-κB
  3. NF-κB
  4. Avenanthramide-C methyl ester

Avenanthramide-C methyl ester 

目录号: HY-138284
产品使用指南

摩尔计算器

Avenanthramide-C methyl ester 是一种抗炎剂和 NF-κB 抑制剂，可抑制促炎因子分泌。Avenanthramide-C methyl ester 通过抑制 IKK 和 IκB 磷酸化以及抑制蛋白酶体活性，抑制 NF-κB 激活。

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Avenanthramide-C methyl ester Chemical Structure

Avenanthramide-C methyl ester Chemical Structure

CAS No. : 955382-52-2

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Avenanthramide-C methyl ester 相关抗体

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity[1].

体外研究
(In Vitro)

Avenanthramide-C methyl ester (40, 100 μM; 24 h) 可剂量依赖性地降低内皮细胞 (HAEC) 中的 mRNA 表达以及 IL-6、IL-8 和 MCP-1 的分泌[1]。
抑制 IL-1β 和 TNFα 刺激的 NF-κB 激活[1]。
Avenanthramide-C methyl ester (1-100 μM; 24 h) 抑制由 TNFR 相关因子 2 和 6（TRAF2、TRAF6）以及 NFκB 诱导激酶 (NIK) 激活的 NFκB 依赖性报告基因表达[1]。
Avenanthramide-C methyl ester 还剂量依赖性地降低 IκB 激酶 (IKK) 和 IκB 的磷酸化水平，并通过蛋白质印迹测量阻止 IκB 降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avenanthramide-C methyl ester 相关抗体:

Western Blot Analysis[1]

Cell Line: WB HAEC and HUVEC cells
Concentration: 1, 10, 40, and 100 μM
Incubation Time: 24 h
Result: Inhibited NF-κB p50 and p65 DNA binding activity of nuclear.
Suppresseed IL-1β-stimulated secretion of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
Inhibited the phosphorylation of IKKα/IKKβ and IκB and degradation of IκB induced by IL-1β.

RT-PCR[1]

Cell Line: WB HAEC and HUVEC cells
Concentration: 40, and 100 μM
Incubation Time: 24 h
Result: Suppressed IL-1β-stimulated mRNA expression of IL-6, IL-8, and MCP-1 by HAEC in a concentration-dependent manner.
分子量

329.30

Formula

C17H15NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avenanthramide-C methyl ester 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avenanthramide-C methyl ester955382-52-2NF-κBNuclear factor-κBNuclear factor-kappaBAtherosclerosisEndothelial cellCytokinesHAECHUVECInhibitorinhibitorinhibit

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Avenanthramide-C methyl ester
目录号：
HY-138284
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