2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Kinesin Apoptosis
  4. AZD4877

AZD4877是 Ispinesib (HY-50759)的另一种构型，是纺锤体驱动蛋白 (kinesin) (Eg5) 抑制剂，对其 IC50 值为 2 nM。 AZD4877 能够阻止细胞有丝分裂，并导致形成单极纺锤体表型，介导细胞凋亡(Apoptosis)。 AZD4877 能够抑制循环外周血单核细胞 (PBMC)，具有抗肿瘤活性。

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AZD4877 Chemical Structure

AZD4877 Chemical Structure

CAS No. : 758722-49-5

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Customer Review

AZD4877 相关抗体

Top Publications Citing Use of Products

查看 Kinesin 亚型特异性产品:

查看所有亚型
Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity[1][2][3][4][5].

IC50 & Target

IC50: 2 nM (Eg5)[5]
体外研究
(In Vitro)

AZD4877 (10 nM, 24 or 48 hours) 诱导人膀胱癌细胞凋亡，且对 AZD4877 敏感的细胞通常高表达 p63[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZD4877 相关抗体:

Apoptosis Analysis[2]

Cell Line: UC1, UC3, UC6, UC12, UC15, RT4,JB,BV, T24 cell line
Concentration: 10 nM
Incubation Time: 24 or 48 hours
Result: Induced apoptosis in human bladder cancer cells
体内研究
(In Vivo)

AZD4877 (静脉注射, 6 或 12 mg/kg；单次) 在大鼠中空纤维模型中，给药后 48 小时使大鼠细胞活力显著降低，裂解的 caspase3 水平增加[1]。
AZD4877 (静脉注射, 6 mg/kg；单次)在 Hans Wistar 大鼠中半衰期为 3.5 h，血浆清除率为 36 mL/min/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

503.66

Formula

C28H33N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZD4877 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD4877758722-49-5AZD 4877AZD-4877KinesinApoptosisColo205KSP inhibitorEg5rat hollow fiber modelUC3Inhibitorinhibitorinhibit

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产品名称：
AZD4877
目录号：
HY-13224
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