2. GPCR/G Protein
  3. Guanylate Cyclase
  4. BAY-747

BAY-747  (Synonyms: BAY 1165747)

目录号: HY-153369
产品使用指南

摩尔计算器

BAY-747 (BAY 1165747) 是一种口服有效和脑渗透性的可溶性鸟苷酸环化酶 (sGC) 刺激剂。BAY-747 可逆转 L-NAME 诱导的记忆障碍并增强大鼠的认知。BAY-747 还能降低有意识的血压正常和自发性高血压大鼠 (SHR) 的血压。BAY-747 可改善 mdx/mTRG2 小鼠模型中与 Duchenne 肌营养不良症 (DMD) 相关的骨骼肌功能。

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BAY-747 Chemical Structure

BAY-747 Chemical Structure

CAS No. : 1609342-18-8

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规格 价格 是否有货
1 mg ￥4200
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Customer Review

BAY-747 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model[1][2][3].

IC50 & Target

Soluble guanylate cyclase (sGC)[1]
体外研究
(In Vitro)

BAY-747 (100 nM) 与 WS 组合使用，可增强体外采集样 cLTP 模型中 AMPA 受体动力学[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-747 相关抗体:

Western Blot Analysis[1]

Cell Line: ex vivo acquisition-like cLTP model
Concentration: 100 nM
Incubation Time:
Result: Increased the phosphorylation levels of S845 on GluA1.
体内研究
(In Vivo)

BAY-747 在研究的时间范围内显示出 0.6 ± 2.0 的脑血浆比，反映出 60% 的相对较高的脑渗透[1]。
BAY-747（0.03-1.0 mg/kg，2 mL/kg；口服；在 24 小时间隔 OLT 中 T1 前 30 分钟）增强大鼠对象定位任务 (OLT) 模型中的长期记忆获取过程，并减弱 L -NAME 引起短期记忆障碍。 BAY-747 不影响海马体中含有 GluA1 的 AMPAR 动力学[1]。
BAY-747（0.003-0.3 mg/kg；口服；单剂量）降低大鼠的血压，并且（3 mg/kg；口服；每天一次，持续 35 天）增加接受 l-NAME 处理的肾素的大鼠体重 转基因模型[2]。
BAY-747（150 mg/kg 食物；口服；16 周）提高雄性 mdx/mTRG2 小鼠的握力和跑步速度，表明骨骼肌功能得到改善[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat object location task (OLT) model[1]
Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: PO; 30 min before T1 in a 24 h interval OLT
Result: Resulted significantly higher long-term memory performance at 0.03, 0.1, 0.3 and 1.0 mg/kg dose, 30 min before T1.
Attenuated L-NAME induced short-term memory impairments at 0.3 mg/kg and 1 mg/kg.
Did not enhance GluA1 trafficking at 1 mg/kg 24 h after treatment.
Animal Model: Anesthetized, conscious spontaneously hypertensive and conscious normotensive rats[2]
Dosage: 0 mg/kg, 0.003 mg/kg, 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, and 0.3 mg/kg
Administration: IV; single dose
Result: Produced a dose-dependent and long-lasting decrease in blood pressure in rats.
Animal Model: l-NAME-Treated Renin Transgenic Rats[2]
Dosage: 0.3 mg/kg, 3 mg/kg
Administration: PO; once daily for 35 days; l-NAME treatment: 30 mg/kg, po, for 6 days
Result: Resulted a significant weight gain among rats.
Led to a dose-dependent increase of plasma cGMP. Decreased blood pressure only at 3 mg/kg.
分子量

416.46

Formula

C22H26F2N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BAY-747 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-7471609342-18-8BAY 1165747BAY747BAY 747BAY1165747BAY-1165747Guanylate CyclaseInhibitorinhibitorinhibit

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