1. Cell Cycle/DNA Damage Neuronal Signaling Epigenetics
  2. Tau Protein HDAC Cholinesterase (ChE)
  3. BChE/HDAC6-IN-2

BChE/HDAC6-IN-2 (compound 29a) 是 BChEHDAC6 的双重抑制剂,IC50 分别为 1.8 nM 和 71.0 nM。BChE/HDAC6-IN-2 具有显着的神经保护作用和活性氧 (ROS) 清除活性。BChE/HDAC6-IN-2 也是金属离子 (Fe2+ 和 Cu2+)的有效螯合剂。BChE/HDAC6-IN-2 抑制 tau 磷酸化,并表现出中等的免疫调节作用。

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BChE/HDAC6-IN-2 Chemical Structure

BChE/HDAC6-IN-2 Chemical Structure

CAS No. : 2925457-33-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

IC50 & Target

IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)

体外研究
(In Vitro)

BChE/HDAC6-IN-2 (compound 29a) (0.1 μM,1 μM;24 小时) 在 10 μM Aβ(1-42) 处理的 SH-SY5Y 细胞中增加 α-微管蛋白的乙酰化水平,抑制 tau 的磷酸化[1]
BChE/HDAC6-IN-2 (5 μM、10 μM、20 μM) 抑制 SH-SY5Y 细胞中谷氨酸诱导的损伤,显示出神经保护作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

474.55

Formula

C27H30N4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
BChE/HDAC6-IN-2
目录号:
HY-149418
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