2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Bcl-2-IN-9

Bcl-2-IN-9 是一种新型、促凋亡的 Bcl-2 抑制剂，IC50 为 2.9 μM，细胞毒性低。Bcl-2-IN-9 通过下调 Bcl-2 表达介导癌细胞凋亡 (apoptosis)，并对白血病细胞具有高选择性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Bcl-2-IN-9 Chemical Structure

Bcl-2-IN-9 Chemical Structure

CAS No. : 2490542-33-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Bcl-2-IN-9 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells[1].

IC50 & Target

Bcl-2

2.9 μM (IC50, [1])

体外研究
(In Vitro)

Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) inhibits HL-60 cells in vitro[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) shows low cytotoxic effects against WI-38 cells with cell viability of 91%[1].
Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) displays a high selectivity against leukemia cells[1].
Bcl-2-IN-9 (compound 6e) (10 μM) mediates apoptotic by down-regulating expression of Bcl-2 and causing chromatin compaction and nuclear fragmentation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-9 相关抗体:

Cell Viability Assay[1]

Cell Line: HL-60 cells
Concentration: 1, 10, 20, 40 μM
Incubation Time: 48 hours
Result: Surpressed cell growth and viability to 28.9%.

Cell Cytotoxicity Assay[1]

Cell Line: WT-38 cells
Concentration: 10 μM
Incubation Time: 48 hours
Result: Low cytotoxic effects.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 1, 10, 20, 40 μM
Incubation Time: 48 hours
Result: Caused chromatin compaction and nuclear fragmentation.
分子量

533.65

Formula

C27H31N7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bcl-2-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-92490542-33-9Bcl-2 FamilyApoptosisBcl-2 inhibitorQuinoxalinequinoxaline-1,3,4-oxadiazole hybrid derivativesAnti-apoptotic protein Bcl-2Anticancer activityMolecular modellingProapoptoticInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Bcl-2-IN-9
目录号：
HY-149009
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z