2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Belantamab mafodotin

Belantamab mafodotin  (Synonyms: GSK2857916; Belantamab mafodotin-blm)

目录号: HY-P3239 纯度: 99.60%
COA

摩尔计算器

Belantamab mafodotin (GSK2857916) 是由人源化、聚焦化的抗 B 细胞成熟抗原 (BCMA) 单克隆抗体和 McMMAF 组成，具有抗骨髓瘤活性。

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Belantamab mafodotin Chemical Structure

Belantamab mafodotin Chemical Structure

CAS No. : 2050232-20-5

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规格 价格 是否有货 数量
1 mg ￥3600
In-stock
5 mg ￥9400
In-stock
10 mg   询价  
50 mg   询价  

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Belantamab mafodotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity[1][2].

体外研究
(In Vitro)

Belantamab mafodotin binds to human BCMA protein with a Kd of 1 nM[2].
Belantamab mafodotin induces G2/M arrest in multiple myeloma cells in a dose and time dependent manner[2].
Belantamab mafodotin signifcantly promotes phagocytosis of multiple myeloma cells by human macrophages derived from macrophage colony-stimulating factor-stimulated monocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belantamab mafodotin 相关抗体:
体内研究
(In Vivo)

Belantamab mafodotin signifcantly improves survival compared to vehicle in mice harbouring OPM2 tumours[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice harbouring OPM2 tumours[2]
Dosage: 4 mg/kg
Administration: IP, twice weekly for 4 doses
Result: Signifcantly improves survival compared to vehicle.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.60%

COA (172 KB) RP-HPLC (251 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Belantamab mafodotin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belantamab mafodotin2050232-20-5GSK2857916 Belantamab mafodotin-blmGSK 2857916GSK-2857916Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesmultiple myelomaDREAMM-2immunoconjugateB-cell maturation antigenanti-myelomaInhibitorinhibitorinhibit

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