2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. Benzosceptrin C

Benzosceptrin C 是一种程序性细胞死亡配体 (PD-L1) 抑制剂，可促进 PD-L1 在通过溶酶体途径降解，增强 T 细胞的细胞毒性并表现出抗肿瘤活性。

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Benzosceptrin C Chemical Structure

Benzosceptrin C Chemical Structure

CAS No. : 1204605-36-6

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Benzosceptrin C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Benzosceptrin C is an inhibitor for PD-L1, which promotes programmed cell death ligand (PD-L1) degradation in a lysosomal pathway, enhances the cytotoxicity of T-cells and exhibits antitumor activity[1].

体外研究
(In Vitro)

Benzosceptrin C (0-10 μM) 抑制 CRC 癌细胞中的 PD-L1 表达，通过破坏 PD-L1 检查点增强 T 细胞的细胞毒性，并抑制 CRC 癌细胞 RKO 和 HCT116 的增殖[1]。
Benzosceptrin C (0-10 μM) 通过抑制 DHHC3 的活性阻断 PD-L1 的棕榈酰化，从而促进 PD-L1 的溶酶体降解，阻断 PD-L1 与 PD-1 的直接相互作用，发挥免疫抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Benzosceptrin C 相关抗体:

Cell Proliferation Assay[1]

Cell Line: RKO and HCT116
Concentration: 0-10 μM
Incubation Time: 24 days
Result: Inhibited proliferation of tumor cells in dose-dependent manner.

Western Blot Analysis[1]

Cell Line: RKO and HCT116
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Reduced levels of PD-L1 in time- and dose-dependent manner.
体内研究
(In Vivo)

Benzosceptrin C (5-50 mg/kg/day，腹腔注射，16 天) 通过激活肿瘤浸润 T 细胞和诱导细胞凋亡 (apoptosis) 抑制 MC38 异种移植 C57BL/6 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 xenograft C57BL/6 mice[1]
Dosage: 5-50 mg/kg
Administration: i.p.,Once a day for 16 days
Result: Inhibited tumor growth with TGI of 30.4% and 43.1% at dose of 25 and 50 mg/kg with presence of T cells.
分子量

774.06

Formula

C22H18Br4N10O2
CAS 号
结构分类
初始来源

sponge Agelas sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Benzosceptrin C 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzosceptrin C1204605-36-6PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1MC38colorectal cancerCRCprogrammed cell deathPD-1programmed cell death ligandPD-L1RKOHCT116C57BL/6 miceInhibitorinhibitorinhibit

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