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  2. Aminoimidazole carboxamide ribotide (AICAR)

Aminoimidazole carboxamide ribotide (AICAR)氨基咪唑羧酰胺核苷酸

释义:

Aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme in Salmonella enterica. Aminoimidazole carboxamide ribotide (AICAR) accumulates and indirectly inhibits synthesis of the essential coenzyme thiamine pyrophosphate (TPP).

氨基咪唑羧酰胺核苷酸 (AICAR),是一种嘌呤生物合成中间体,是肠道沙门氏菌中 AICAR 转化酶/IMP 环水解酶 (PurH) 的底物。氨基咪唑羧酰胺核苷可累积并间接抑制必需辅酶硫胺焦磷酸 (TPP) 的合成。

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