2. Cytoskeleton Metabolic Enzyme/Protease
  3. Dynamin HIV Integrase
  4. Bis-T-23

Bis-T-23 (AG1717)，tyrphostin 衍生物，是一种 HIV-I 整合酶抑制剂。 Bis-T-23 可以促进肌动蛋白依赖性动力蛋白寡聚化。 Bis-T-23 可用于 HIV 以及慢性肾脏病（CKD）的研究。

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Bis-T-23 Chemical Structure

Bis-T-23 Chemical Structure

CAS No. : 171674-76-3

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规格 价格 是否有货 数量
1 mg ￥3995
1 周
5 mg   询价  
10 mg   询价  

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Bis-T-23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].

体外研究
(In Vitro)

Bis-T-23 (AG1717) (0.18 μM) 可抑制 HIV-1 整合酶[2]。
AG1717 (2 μM) 可抑制整合酶与底物的结合 DNA[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-T-23 相关抗体:
体内研究
(In Vivo)

Bis-T-23 (1 ng) 靶向足细胞中肌动蛋白依赖性动力蛋白寡聚化，以促进正常的 GFB 功能[1]。
Bis-T-23 (i.p.; 20, 40 mg/kg) 通过改变肌动蛋白动力学改善蛋白尿[1]。
Bis-T-23 (i.p.; 20, 40 mg/kg) 在啮齿类动物的多种遗传和慢性肾小球疾病模型中改善或预防蛋白尿并减少系膜基质扩张[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (8 weeks old, males); Mice[1]
Dosage: 20, 40 mg/kg; 40 mg/kg
Administration: Intraperitoneal injection; signle, once for 6 consecutive days
Result: Specifically reduced proteinuria on days 18 and 24.
Caused a transient reduction of proteinuria (single dose) in PKCε KO mice.
Completely prevented the onset of high-level proteinuria in the CD2AP KO mice.
Significantly extended the lifespans of CD2AP KO mice.
Led to improved glomerular histology with less mesangial matrix accumulation.
Animal Model: Zebrafish[1]
Dosage: 1 ng
Administration: Injection
Result: Promoted oligomerization of zebrafish Dyn2.
Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.
分子量

480.43

Formula

C23H20N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bis-T-23 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-T-23171674-76-3AG1717AG 1717AG-1717DynaminHIV Integrasechronic kidney diseases (CKD)proteinuriaglomerular filtration barrier (GFB)dynaminactin cytoskeletonHIV integraseInhibitorinhibitorinhibit

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目录号：
HY-123572
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