1. Apoptosis
  2. TNF Receptor
  3. C 87

C 87 是一种新型小分子 TNFα 抑制剂; 高效抑制 TNFα 诱导的细胞毒性,IC50 值为 8.73 μM。

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C 87 Chemical Structure

C 87 Chemical Structure

CAS No. : 332420-90-3

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10 mM * 1 mL in DMSO ¥890
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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

IC50 & Target

IC50: 8.73 μM (TNFα-induced cytotoxicity)[1]

体外研究
(In Vitro)

87 (C87) 直接结合 TNFα,有效抑制 TNFα 诱导的细胞毒性 (IC50=8.73 μM) 并有效阻断 TNFα 触发的信号传导活动。C 87 在体外表现出良好的溶解性和一致的剂量依赖性功能。C 87 完全阻断 TNFα 诱导的 caspase-3caspase-8 激活。在 L929 细胞中,c-Jun 氨基末端激酶 (JNK) 的活性会被 C 87 显著降低。C 87 还可以防止用 TNFα 处理的细胞中 IκBα 的降解。C 87 有效阻断由 TNFα 触发的多个信号转导通路和下游靶基因激活[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

C 87 (C87) 可减轻 TNFα 诱导的炎症,从而显著减少肝脏损伤并提高动物存活率。与载体对照相比,C 87 注射延迟了死亡发生率并将存活率提高了两倍。在接受 C 87 处理的小鼠中,丙氨酸转氨酶和天冬氨酸转氨酶的水平持续降低[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

502.93

Formula

C24H15ClN6O3S

CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5.05 mg/mL (10.04 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9883 mL 9.9417 mL 19.8835 mL
5 mM 0.3977 mL 1.9883 mL 3.9767 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Cell Assay
[1]

The inhibition of the cytotoxic effect of human TNFα by compounds (C 87) is measured in L929 cell line. L929 cells are seeded at a density of 104 cells/well in a 96-well plate and incubated for 24 h in RPMI 1640 with 10% FBS at 37°C. Compounds (C 87) are added to the cells with 1 μg/mL actinomycin D and 1 ng/mL TNFα and then incubated at 37 °C for 20 h before analysis. Cell survival is measured using the MTT method[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

BALB/c mice are used in the study. Before LPS/GalN challenge (LPS (50 μg/kg) and D-GalN (1.2g/kg)), mice are injected intraperitoneally with C 87 (12.5 mg/kg), Enbrel (4 mg/kg), or vehicle, respectively, at 1, 8, and 16 h. Blood is collected with retro-orbital sampling. Activities of alanine transaminase and aspartate transaminase are detected. Liver tissues are collected and fixed in 10% formalin, and sections are stained with hematoxylin and eosin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

C 87 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9883 mL 9.9417 mL 19.8835 mL 49.7087 mL
5 mM 0.3977 mL 1.9883 mL 3.9767 mL 9.9417 mL
10 mM 0.1988 mL 0.9942 mL 1.9883 mL 4.9709 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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