1. Metabolic Enzyme/Protease Anti-infection Apoptosis Autophagy
  2. Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy
  3. Calcimycin hemimagnesium

Calcimycin hemimagnesium  (Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

目录号: HY-N6687B
产品使用指南

Calcimycin (A-23187) hemimagnesium 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore),如钙离子和镁离子。Calcimycin hemimagnesium 通过增加细胞内钙浓度诱导 Ca2+ 依赖性细胞死亡。Calcimycin hemimagnesium 抑制革兰氏阳性细菌和一些真菌的生长,还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS),诱导细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Calcimycin hemimagnesium Chemical Structure

Calcimycin hemimagnesium Chemical Structure

CAS No. : 72124-77-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Calcimycin hemimagnesium 的其他形式现货产品:

Customer Review

Other Forms of Calcimycin hemimagnesium:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].

体外研究
(In Vitro)

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Clinical Trial
分子量

1069.53

Formula

C58H72MgN6O12

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Calcimycin hemimagnesium
目录号:
HY-N6687B
需求量: