2. Anti-infection
  3. Bacterial Antibiotic
  4. Callophycin A

Callophycin A 是一种红海藻衍生代谢物，对白色念珠菌 (Candida albicans) 有明显的抑制作用，MIC 为 62.5~250 mg/L。Callophycin A 显著降低阴道念珠菌感染小鼠的载菌量，并能降低炎症反应以及免疫分子的产生。

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Callophycin A Chemical Structure

Callophycin A Chemical Structure

CAS No. : 1345674-93-2

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Callophycin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules[1].

IC50 & Target

MIC: 62.5~250 mg/L (Candida albicans)[1]
体内研究
(In Vivo)

Callophycin A (1%; for 5 days) dramatically reduces CFU of Candida albicans; and significantly reduces the amount of IL-6, IL-12, IL-17 and IL-22 compared with disease control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss albino mice (infected with Candida albicans)[1]
Dosage: 1%
Administration: For 5 days
Result: Dramatically reduces CFU of Candida albicans from about 400 to 100/ml; and significantly (p < 0.001) reduces the amount of IL-6 (2.71 ± 0.09 to 1.83 ± 0.03 pg/µl), IL-12 (7.33 ± 0.15 to 6.13 ± 0.15 pg/µl), IL-17 (17.83 ± 0.21 to 13.70 ± 0.2 pg/µl) and IL-22 (5.33 ± 0.25 to 4.20 ± 0.26 pg/µl) compared with disease control group.
分子量

322.36

Formula

C19H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Callophycin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Callophycin A1345674-93-2BacterialAntibioticred seaweed derived metaboliteC. albicansdrug resistance vaginal candidiasisDrug resistanceCandida albicansInhibitorinhibitorinhibit

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HY-146190
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