2. Immunology/Inflammation
  3. Interleukin Related
  4. Canakinumab

Canakinumab  (Synonyms: 卡那奴单抗; Ilaris; ACZ 885)

目录号: HY-108810 纯度: 99.64%
COA

摩尔计算器

Canakinumab (ACZ885) 是一种重组的人抗 IL-1β 单克隆抗体。Canakinumab 显示出对人类和绒猴 IL-1β 的 IC50 值为分别为 43.6 和 40.8 pM。Canakinumab 的作用模式是基于对 IL-1β 信号的中和，从而抑制与自身免疫性疾病相关的炎症。

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Canakinumab Chemical Structure

Canakinumab Chemical Structure

CAS No. : 914613-48-2

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1 mg ￥6000
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Canakinumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Human
IC50 & Target

IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2]
体外研究
(In Vitro)

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Canakinumab 相关抗体:
Clinical Trial
CAS 号
Unlabeled CAS

性状

液体

颜色

Colorless to light yellow

中文名称

卡那奴单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.64%

COA (172 KB) SDS-PAGE (116 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Canakinumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canakinumab914613-48-2Ilaris ACZ 885卡那奴单抗ACZ885ACZ 885ACZ-885Interleukin RelatedILrecombinanthumanmonoclonalantibodyautoimmuneIL-6IL-1RIIL-1RIIInhibitorinhibitorinhibit

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目录号：
HY-108810
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