2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphatase Apoptosis
  4. Cantharidic acid disodium

Cantharidic acid disodium 是酸酐 Cantharidin 的水解产物，可诱导多种人类癌细胞凋亡 (apoptosis)。Cantharidic Acid disodium 是一种选择性蛋白磷酸酶 2 (PP2A) 和 PP1 抑制剂，IC50 值分别为 50 nM 和 600 nM。

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Cantharidic acid disodium Chemical Structure

Cantharidic acid disodium Chemical Structure

CAS No. : 1465-77-6

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Cantharidic acid disodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC50 values of 50 nM and 600 nM, respectively[1][2].

体外研究
(In Vitro)

Cantharidic acid（0-20 μM；24 小时）显着降低细胞活力，这是通过外源性和内源性细胞凋亡途径中 caspase 激活的上调以及 ERK1/2、p38 和 JNK1/2 途径的上调来揭示的[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cantharidic acid disodium 相关抗体:

Cell Viability Assay[1]

Cell Line: HONE-1, NPC-39, and NPC-BM
Concentration: 0, 2.5 μM, 5 μM, 10 μM, or 20 μM
Incubation Time: 24 h
Result: Markedly reduced cell viability.

Apoptosis Analysis[1]

Cell Line: HONE-1, NPC-39
Concentration: 0, 2.5 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Led to apoptosis in human nasopharyngeal carcinoma (NPC) cells through the upregulation of caspase activation.

Western Blot Analysis[1]

Cell Line: HONE-1, NPC-39
Concentration: 0, 2.5 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Showed the upregulation of caspase activation in extrinsic and intrinsic apoptosis pathways as well as the upregulation of ERK1/2, p38, and JNK1/2 pathways.
体内研究
(In Vivo)

Cantharidic acid（10 mg/kg；腹腔注射；一次）会导致小鼠肝脏极度肿大和充血。血糖和肝糖原磷酸化酶水平升高以及肝糖原含量和糖原合成酶活性相应降低可以证明肝糖原分解增加[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

258.18

Formula

C10H12Na2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cantharidic acid disodium 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantharidic acid disodium1465-77-6PhosphataseApoptosisPP2A/PP1 inhibitorCantharidinapoptosisERK1/2p38and JNK1/2Inhibitorinhibitorinhibit

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