2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB2 receptor agonist 2

CB2 receptor agonist 2 

目录号: HY-132217 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

CB2 receptor agonist 2 是 CB2 受体的有效和选择性激动剂。对 CB2 的 Ki 为 8.5 nM。CB2 receptor agonist 2 对 CB2 具有高亲和力和选择性。

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CB2 receptor agonist 2 Chemical Structure

CB2 receptor agonist 2 Chemical Structure

CAS No. : 1314230-75-5

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规格 价格 是否有货 数量
5 mg ￥4086
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CB2 receptor agonist 2 相关抗体

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1].

IC50 & Target[1]

CB2

8.5 nM (Ki)

体外研究
(In Vitro)

CB2 receptor agonist 2 (compound 4g) (1  μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Hep-G2 (Human hepatoblastoma) cells
Concentration: 1  μM
Incubation Time: 72 hours
Result: Exhibited very low or no cytotoxicity to Hep-G2 cells.
体内研究
(In Vivo)

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1]
Dosage: Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour
Administration: Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)
Result: Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.
分子量

488.62

Formula

C30H36N2O4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 30 mg/mL (61.40 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0466 mL 10.2329 mL 20.4658 mL
5 mM 0.4093 mL 2.0466 mL 4.0932 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (201 KB)

产品使用指南 (1538 KB)
参考文献

CB2 receptor agonist 2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.0466 mL 10.2329 mL 20.4658 mL 51.1645 mL
5 mM 0.4093 mL 2.0466 mL 4.0932 mL 10.2329 mL
10 mM 0.2047 mL 1.0233 mL 2.0466 mL 5.1165 mL
15 mM 0.1364 mL 0.6822 mL 1.3644 mL 3.4110 mL
20 mM 0.1023 mL 0.5116 mL 1.0233 mL 2.5582 mL
25 mM 0.0819 mL 0.4093 mL 0.8186 mL 2.0466 mL
30 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7055 mL
40 mM 0.0512 mL 0.2558 mL 0.5116 mL 1.2791 mL
50 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
60 mM 0.0341 mL 0.1705 mL 0.3411 mL 0.8527 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2 receptor agonist 21314230-75-5Cannabinoid Receptoraffinityselectivityselective human hepatoblastomacannabinoidInhibitorinhibitorinhibit

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