2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-8

CDK4/6-IN-8 (Compound 7p) 是一种选择性的 CDK4 和 CDK6 抑制剂，其 IC50 值分别为 5.01 nM 和 3.97 nM。

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CDK4/6-IN-8 Chemical Structure

CDK4/6-IN-8 Chemical Structure

CAS No. : 2649120-22-7

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CDK4/6-IN-8 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].

IC50 & Target

CDK4

5.01 nM (IC50)

CDK6

3.97 nM (IC50)

体外研究
(In Vitro)

CDK4/6-IN-8 (Compound 7p) (0-656.1 µM, 48 h) shows anti-breast cancer activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK4/6-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7
Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7 and 656.1 µM
Incubation Time: 48 h
Result: Inhibited cell viability with an IC50 of 2.8 μM.
分子量

398.37

Formula

C18H18N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK4/6-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-82649120-22-7CDKCyclin dependent kinaseselective CDK4/6 inhibitorMCF-7anti-breast cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-143258
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